Muscle Flashcards
Where is CK-MB found?
Heart
Where is CK-MM found?
Muscle
Where is CK-BB found?
Brain
Why should you wait 30 min after a meal before swimming?
All blood in gut and skeletal mm have ran out of ATP
How does a neurogenic muscle disease present?
Distal weakness & fasciculations
How does a myopathic muscle disease present?
Proximal weakness & pain
What is a light chain composed of?
Actin
What is a heavy chain composed of?
Myosin
What band of the sarcomere does not change length?
A-band
Where are the T-tubules located?
Cardiac muscle: Z line
Skeletal muscle: A-band junction with I-band
What is Duchenne’s MD?
Dystrophin mutation
Frameshift mutation
Gower’s sign
Calf pseudohypertrophy
What is Becker’s MD?
Dystrophin mutation
Missense mutation
Sx >5y
What is myotonic dystrophy?
Bird’s beak face
Cannot let go when shaking hands
What is myasthenia syndrome (= Lambert-Eaton)?
Gets stronger as day goes by
Stronger w/ EMG
Not associated w/ small cell carcinoma
What is Myasthenia gravis?
Gets weaker as day goes on
Stronger w/ edrophonium
Weaker w/ EMG
Rule out thymoma
What is multiple sclerosis?
Anti-myelin Ab
Young woman w/ vision problems
Sx come and go
What is metachromatic leukodystrophy?
Arylsulfatase deficiency
Kid w/ MS presentation
What is Ataxia Telangiectasia?
Spider veins
d/t IgA deficiency
What is Friedrich’s ataxia?
Retinitis pigmentosa
Scoliosis
What is Adrenal Leukodystrophy?
Carnitine shuttle problem
Adrenal failure
What is Guillain-Barre?
Ascending paralysis
2 weeks after URI
What is ALS?
Middle age male w/ fasciculations
Descending paralysis
No sensory problems
What is Werdnig-Hoffman?
Fasciculations in a newborn
No anterior horns
What is Polio?
Asymmetric fasciculations in child
2 weeks after gastroenteritis
