Main Concepts Flashcards

1
Q

What electrolytes does the low volume state have?

A

Elevated total Na+
Elevated pH (alkalotic)
Decreased serum Na+ (dilution effect)
Decreased serum Cl-
Decreased serum K+
Decreased Ca++ (bound to Albumin)

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2
Q

What pH does the low volume state have?

A

Alkalotic b/c Aldosterone dumps H+

(Not diarrhea, RTA Type II, and DKA)

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3
Q

What pH do vomiters have?

A

Form of low volume state:
Alkalotic

(Since you vomit out H+)

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4
Q

What pH does diarrhea have?

A

Exception for low volume state:
Acidotic

(b/c stool has bicarbonate from pancreas that has not had adequate time to be reabsorbed)

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5
Q

What is cause if pulse is >10 mmHg on standing?

A

Hypovolemic shock

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6
Q

What is cause if pulse is <5 mmHg on standing?

A

Autonomic dysfunction

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7
Q

What are symptoms of a low energy state?
(CNS)

A

Mental retardation
Dementia
Decreased activity

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8
Q

What are symptoms of a low energy state?
(CV)

A

Heart failure
Pericardial effusion

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9
Q

What are symptoms of a low energy state?
(Muscle)

A

Weakness
SOB
Vasodilation
Impotence
Urinary retention
Constipation

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10
Q

What are symptoms of a low energy state?
(Rapidly dividing cells)

A

Skin = dry
Cuticles = brittle nails
Hair = alopecia
Bone marrow = suppressed
Vascular endothelium = breaks down; vasculitis
Lungs = infection, SOB
Kidney = PCT (first portion affected)
GI = N/V/D
Bladder = urinary retention
Sperm = decreased
Germ cells = predisposed to cancer
Breasts = atrophic
Endometrium = amenorrhea, atrophic

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11
Q

What are most common signs of the low energy state?

A

Tachypnea
Dyspnea

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12
Q

What are the most common symptoms of the low energy state?

A

Weakness
SOB

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13
Q

What are the most common infections of the low energy state?

A

UTI
Respiratory infections

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14
Q

What is the most common cause of death in the low energy state?

A

Heart failure

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15
Q

Parameters of restrictive lung diseases

A

interstitial problem (non-bacterial)
Decreased diffusion and perfusion

Decr VC = small stiff lungs
FEV1/FVC >0.8 => trouble breathing in
ABG: decr pO2 => elev RR, decr pCO2, elev pH
CXR: reticulo-nodular pattern, ground-glass appearance
Die of cor pulmonale
Ex: NM diseases (breathing out is passive), drugs, autoimmune dz
Tx: pressure support on ventilator, incr O2, incr RR, incr inspiration time, decr tidal volume

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16
Q

Parameters of obstructive lung diseases

A

Airway problem (bacterial)

Big, mucus-filled lungs (elev Residual volume, elev Reid index = incr airway thickness/airway lumen)
FEV1/FVC <0.8 => trouble breathing out
ABG: elev pCO2 => elev RR, low pH
Die of bronchiectasis
Ex: COPD
Tx: Manipulate rate on ventilator, incr RR, incr expiratory time, incr O2 only if needed

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17
Q

What symptoms does a “more likely to depolarize” state have?
(Brain)

A

Psychosis
Seizures
Jitteriness

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18
Q

What symptoms does a “more likely to depolarize” state have?
(Skeletal muscle)

A

Muscle spasms
Cramps

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19
Q

What symptoms does a “more likely to depolarize” state have?
(smooth muscle)

20
Q

What symptoms does a “more likely to depolarize” state have?
(Cardiac)

A

Tachycardia
Arrhythmias

21
Q

What symptoms does a “less likely to depolarize” state have?
(Brain)

A

Lethargy
Mental status changes
Depression

22
Q

What symptoms does a “less likely to depolarize” state have?
(Skeletal muscle)

A

Weakness
SOB

23
Q

What symptoms does a “less likely to depolarize” state have?
(smooth muscle)

A

Constipation

24
Q

What symptoms does a “less likely to depolarize” state have?
(Cardiac)

A

Hypotension
Bradycardia

25
What is the humoral immune response?
B cells & PMNs patrol the blood looking for bacteria
26
What is the cell-mediated immune response?
T cells & Macrophages patrol the tissues looking for non-bacteria
27
What are macrophages called in the brain?
Microglia
28
What are macrophages called in the blood?
Monocytes
29
What are macrophages called in the lungs?
T1 pneumocytes
30
What are macrophages called in the liver?
Kupffer cells
31
What are macrophages called in the spleen?
RES cells
32
What are macrophages called in lymph fluid?
Dendritic cells
33
What are macrophages called in the kidney?
Mesangial cells
34
What are macrophages called in Peyer’s patches (GI tract)?
M cells
35
What are macrophages called in the skin?
Langerhans’ cells
36
What are macrophages called in bone?
Osteoclasts
37
What are macrophages called in connective tissue?
Histiocytes Giant cells Epithelioid cells
38
What is the CBC for every vasculitis?
Decreased RBC count Decreased platelets Elevated WBC count Elevated T cells Elevated macrophages Elevated ESR Schistocytes
39
What is the time course of the inflammatory response?
1 hour -> swelling Day 1 -> PMNs show up at 4.5 hours, predominate at 24 hours Day 3 -> PMNs peak Day 4 -> M0/T cells shows up Day 7 -> M0/T cells peak, fibroblasts arrive Day 30 -> Fibroblasts peak Month 3-6 -> Fibroblasts complete fibrosis
40
What state does estrogen mimic?
The neuromuscular disease state (Estrogen is a muscle relaxant)
41
What does high GABA levels lead to?
Bradycardia Lethargy Constipation Impotence Memory loss
42
What is Necrosis?
Non-programmed cell death Noisy Inflammation Nucleus destroyed first
43
What is Apoptosis?
Programmed cell death Quiet No inflammation Nucleus guided
44
What is Pyknosis?
“Pick blobs” Nucleus turns into blobs
45
What is karyohexis?
Nucleus fragments
46
What is Karyolysis?
Nucleus dissolves