Mieloma Multiple Flashcards

1
Q

Hallazgos dx

A

Identificación de una proteína monoclonal M en la electroforesis del suero o orina 97%: IgG (más frec) IgA

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2
Q

Características principales

A

Destruccion ósea
Reemplazo de la médula o sea
Formación de paraproteinas

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3
Q

FR

A

Edad avanzada
Sexo masculino
Agentes ambientales: dioxinas, benceno, solventes orgánicos y Radiación

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4
Q

Presentaciones comunes

A

Dolor óseo (colapso de cuerpos vertebrales)
Debilidad
Fatiga

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5
Q

Causas de insuficiencia renal

A

Depósito de cadenas ligeras
Hipercalcemia
Amiloidosis
AINES

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6
Q

Diagnóstico ✅

A

AMO: >10 % de plasmocitos manoclonales en médula o sea proteína M en el suero o orina

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7
Q

Estadificacion de acuerdo a

A

Niveles de albumina y micro albumina

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8
Q

Hallazgos en radiografía

A

Lesiones liticas en sacabocado
Osteoporosis o fracturas en vértebras cráneo caja torácica pelvis y extremas proximales de húmero y fémur 🦴

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9
Q

Objetivo del tratamiento

A

Control de complicaciones

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10
Q

Tx de hipercalcemia y reducir las complicaciones esqueléticas

A

Bifosfonatos

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11
Q

Tratamiento de enfermedad refractaria

A

Radiación o qx

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12
Q

Porcentaje de candidatos a trasplante

A

50%

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13
Q

Utilidad del trasplante

A

Prolonga la supervivencia

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14
Q

Esquema de remisión

A

Dexa
Lenalidomida
Bortezomib

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15
Q

Tratamiento para no candidatos a trasplante

A

Melfalan y prednisona con talidomida MPT o bortezomid VMP

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16
Q

Supervivencia media

A

3 años