Microstructure Of Bone Flashcards

1
Q

What type of collagen is bone extracellular matrix

A

Type I - 90% of total protein highly organised fibres

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2
Q

What forms the osteoid in bone

A

Non collagenous proteins (glycoproteins and proteoglycans) and bone extracellular matrix

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3
Q

What are the 5 functions of bone

A

Protection
Support
Movement
Reservoir
Blood cell formation

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4
Q

What is cortical bone

A

The mature form of bone which the bundles of collagen fibres in bone matrix are organised into successive sheets or lamellae

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5
Q

What does the cortical bone form

A

The internal and external parts of flat bones and the external surfaces of long bones

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6
Q

What is the primary structural unit of cortical bone

A

An osteon also known as a Haversian system

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7
Q

What do insides of the bone contain

A

Trabecular bone like a honey comb

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8
Q

What is in between the spaces of bone and what do they make

A

Fluid bone marrow cells which make blood and some fat cells

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9
Q

What makes up 80% of the skeletal mass

A

Cortical bone

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10
Q

What makes up 20% of the skeletal mass

A

Cancellous/trabecular bone (spongy bone)

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11
Q

What is the difference between cortical and cancellous/trabecular bone

A

Cancellous/trabecular is less dense, more elastic and has a higher turnover rate

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12
Q

Where is cancellous/trabecular bone mainly found

A

Axial skeleton: bones of skull, ribs and spine

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13
Q

What is immature bone also known as

A

Woven bone

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14
Q

Where is woven bone found

A

During embryonic development
During fracture healing
In some pathological states

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15
Q

What is woven bone composed of

A

Randomly arranged collagen bundles and irregularly shaped vascular spaces lined with osteoblasts

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16
Q

What replaces woven bone

A

It is remodeled and replaced with cortical or cancellous bone expect in a few places

17
Q

Where is woven bone not replaced

A

Places where tendons insert into bones and the tooth sockets

18
Q

What are the 2 membranes which cover bone surfaces

A

Periosteum
Endosteum

19
Q

What does the periosteum do

A

Around bone
Covers and protects the outer surface of the bones that are not covered by cartilage

20
Q

What is the outer layer of the periosteum

A

A fibrous layer, a dense irregular connective tissue proper, is the protective layer

21
Q

What is the inner layer of the periosteum

A

Is delicate, is osteogenic and contains mainly osteoblasts and osteoclasts

22
Q

How is the periosteum connected to bone

A

With strands of collagen fibres (sharpeys fibres) that extend from its fibrous layer into the bone matrix

23
Q

What is the outer periosteum connected to

A

Tendons, ligaments and the fibrous layer of the articular capsule in synovial joints

24
Q

What is the endosteum

A

Inside bone
An osteogenic membrane
A delicate connective membrane containing mainly osteocytes and osteoclasts

25
Q

What does the endosteum cover

A

All the bones inner cavities that contain marrow and or blood vessels

26
Q

What are osteoblasts

A

Forms the collagen, glycoproteins and proteoglycans of the matrix and controls the deposition of mineral crystals on the fibrils

27
Q

What are osteocytes

A

Mature osteocyte is involved in maintaining the matrix of its territory
Controls extracellular concentration of calcium and phosphorus

28
Q

What are osteoclasts

A

Very large
Multi nucleated
Bone resorbing cells

29
Q

What is the mineral content of alveolar bone

A

70%

30
Q

What is the mineral content of cementum

A

70%

31
Q

What happens at the 3rd week for bone development

A

Notochord develops (rod like structure that later becomes the spine, spinal cord and brain)

32
Q

What happens on the 4th week of bone development

A

First signs of arms and legs

33
Q

What happens on the 5th week of bone development

A

Coccyx forms and arms and legs take on definite shape

34
Q

What happens on the 7th week of bone development

A

One inch long and facial features form

35
Q

What happens on the 8th week of bone development

A

First bone cells appear

36
Q

When does true ossification begin

A

After birth