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MCQ 1.1 > Inflammation > Flashcards

Inflammation Flashcards

1
Q

What is rubor

A

Redness

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2
Q

What is calor

A

Heat

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3
Q

What is tumour

A

Swelling

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4
Q

What is dolor

A

Pain

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5
Q

What is functio laesa

A

Loss of function

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6
Q

What do platelets do during an inflammatory response

A

Release seotonin for initial vasoconstriction restricting blood loss

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7
Q

What do mast cells do during an inflammatory response

A

Release histamine for vasodilation to get more blood to the site

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8
Q

What activates the complement system

A

Fibrinolytic system

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9
Q

What does kinin cascade do during an inflammatory response

A

Forms bradykinin - vasodilation and increase vascular permeability

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10
Q

What does membrane phospholipid release

A

Arachidonic acid

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11
Q

What does arachidonic acid release

A

Leukotrienes
Prostaglandins
Thromboxanes

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12
Q

Where does the inflammatory mediator reaction take place

A

In inflammatory cells and endothelium

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13
Q

What are 2 major inflammatory mediators

A

Cytokines and chemokines

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14
Q

What are 2 pro inflammatory mediators

A

Interleukin - 1
Tumour necrosis factor alpha

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15
Q

What 2 inflammatory mediators induce production of other cytokines

A

Interleukin - 8
Monocyte chemotactic protein MCP

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16
Q

What 3 cells do inflammatory mediators attract

A

Neutrophils
Monocytes
Lymphocytes

17
Q

What are the 4 stages of cellular events in order

A

Margination - rolling - adhesion - transmigration

18
Q

What are the first cells to infiltrate

A

Neutrophils

19
Q

What are neutrophils activated by

A

Bacterial LPS

20
Q

What do neutrophils generate

A

Oxygen free radicals toxic to cells

21
Q

During acute inflammation what anti inflammatory cytokines are released

A

IL - 4
IL - 10

22
Q

In chronic inflammation what 2 cells are involved

A

Maccrophages
Lymphocytes

23
Q

What normally produces inflammatory pain

A

Innocuous stimuli (hyperalgesia)

24
Q

What can inflammatory mediators reduce

A

The threshold of activation of nociceptive sensory neurons

MCQ 1.1 (43 decks)

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