Inflammation Flashcards
What is rubor
Redness
What is calor
Heat
What is tumour
Swelling
What is dolor
Pain
What is functio laesa
Loss of function
What do platelets do during an inflammatory response
Release seotonin for initial vasoconstriction restricting blood loss
What do mast cells do during an inflammatory response
Release histamine for vasodilation to get more blood to the site
What activates the complement system
Fibrinolytic system
What does kinin cascade do during an inflammatory response
Forms bradykinin - vasodilation and increase vascular permeability
What does membrane phospholipid release
Arachidonic acid
What does arachidonic acid release
Leukotrienes
Prostaglandins
Thromboxanes
Where does the inflammatory mediator reaction take place
In inflammatory cells and endothelium
What are 2 major inflammatory mediators
Cytokines and chemokines
What are 2 pro inflammatory mediators
Interleukin - 1
Tumour necrosis factor alpha
What 2 inflammatory mediators induce production of other cytokines
Interleukin - 8
Monocyte chemotactic protein MCP
What 3 cells do inflammatory mediators attract
Neutrophils
Monocytes
Lymphocytes
What are the 4 stages of cellular events in order
Margination - rolling - adhesion - transmigration
What are the first cells to infiltrate
Neutrophils
What are neutrophils activated by
Bacterial LPS
What do neutrophils generate
Oxygen free radicals toxic to cells
During acute inflammation what anti inflammatory cytokines are released
IL - 4
IL - 10
In chronic inflammation what 2 cells are involved
Maccrophages
Lymphocytes
What normally produces inflammatory pain
Innocuous stimuli (hyperalgesia)
What can inflammatory mediators reduce
The threshold of activation of nociceptive sensory neurons
