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MCQ 1.1 > ECM > Flashcards

ECM Flashcards

1
Q

What is ECM

A

The non cellular components present within tissues and organs

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2
Q

What is the ECM composed of

A

Proteins, proteoglycans (carbohydrates) and minerals

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3
Q

What is the most abundant tissue within the body

A

Connective tissue

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4
Q

Give an example of a tissue which is mostly ECM

A

Cartilage

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5
Q

What does the ECM do

A

Strength, Support, Protection, stores and presents growth
Cell adhesion and migration
Acts as a scaffold for tissue repair
A signal for cell function

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6
Q

Where does ECM come from

A

Secreted by cells

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7
Q

What synthesis and maintains the matrix

A

Cells

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8
Q

List 8 types of ECMs found in the oral cavity

A

Basement membrane (epithelia, muscle, fat, nerves)
Elastic tissues (skin, large blood vessels)
Stromal or interstitial matrix
Bone
Tooth
Cartilage
Tendon
Ligament

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9
Q

What are the 5 classes of macromolecules

A

Collagens
Elastic fibres (elastin and fibrillin)
Proteoglcans
Hyaluronan
Adhesive glycoproteins e.g. laminin and fibronectin

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10
Q

List 3 type I collagen main structural protein of ECM

A

Skin
Tendon
Bone

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11
Q

List 2 type II main structural proteins of ECM

A

Cartilage
Vitreous humour

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12
Q

List 2 type III structural proteins of ECM

A

Skin
Muscle

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13
Q

List 1 type IV main structural protein of ECM

A

Basal lamina (meshwork)

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14
Q

What is special about types V-XII main structural protein of ECM

A

Less abundant

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15
Q

What do elastic fibres do

A

Allow tissues to resume their shape after stretching e.g. artery, lung, skin, bladder

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16
Q

How are elastic fibres arranged

A

In crosslinked arrays of tropoelastin

17
Q

What are proteoglycans

A

Protein backbone polysaccharide side chains

18
Q

What is a feature of proteoglycans

A

Large branching which aggregates retaining H2O

19
Q

List 4 glycosaminoglycans

A

Chondroitin sulphate
Heparin sulphate
Keratin sulphate
Hyaluronic acid

20
Q

Where is chondroitin sulphate

A

Hyaline cartilage

21
Q

where is heparin sulphate

A

Basement membrane

22
Q

Where is keratin sulphate

A

Cornea

23
Q

Where is hyaluronic acid

A

Skin, polysaccharide only

24
Q

What are 4 features of proteoglycans

A

Can be small or large
Bind to proteins
Cell surface proteoglycans
Act as co receptors

25
Q

What allows diffusion into cells

A

Alpha and beta integrins

26
Q

What creates ECM

A

Fibroblasts

27
Q

Name 2 adhesive components

A

Laminin and fibronectin

28
Q

Name 2 elastic fibres

A

Elastin and fibrillin

29
Q

What ECM matrix defect causes periodontitis

A

Extensive matrix degradation in disease

MCQ 1.1 (43 decks)

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