Collagen Flashcards
How is the collagen triple helix stabilised
By an interchain hydrogen bonding network involving the hydroxyl group
In collagen what is the every third amino acid
Glycine
What does hydroxyproline do in the primary structure of collagen
Is active in forming covalent cross links via extra H-bonds
What does the primary structure of collagen refer to
The linear number and order of the amino acids present
What does the secondary structure of collagen refer to
Local structure which is typically recognised by specific backbone and specific main chain hydrogen bond pairing
What does the tertiary structure in collagen refer to
The complete three dimensional structure of the polypeptide units of a given protein
What does quarternary structure refer to
The structure formed by monomer-monomer interaction in an oligomeric protein
How does collagen establish a quaternary structure
Collagen molecules align to form microfibrils which then align to form collagen fibres
What are the 2 terminal (ends) of the collagen triple helix
C-telopeptides
N-telopeptides
What is the role of the terminals of the collagen triple helix
Formation of microfibril and fibril
What is the x position of the collagen polypeptide chain occupied by
Proline (Pro)
What is the y position of the collagen polypeptide chain occupied by
Hydroyproline (Hyp)
What are the 3 functions of the polypeptide chain in collagen
Triple helix stability
Intermolecular binding
Binding to extracellular matrix molecules
What does the Gly of the triple helix in collagen do
Help to create ‘tight’ turns
How many collagen molecules make 1 microfibril
5
