Microbiology 22: Opportunistic Viral Infections Flashcards
Which 2 organisms can cause Infective mononucleosis ?
CMV
EBV
Which genetic mutation gives a predisposition to invasive Herpes simplex encephalitis ?
UNC93B
What type of virus is HIV ?
Lentivirus
Which cells does HIV target ?
CD4+ T cells
Which Virus causes Kaposi Sarcoma ?
HHV8
Which virus causes Burkitss lymphoma in HIV patients ?
EBV
Which infections are people receiving anti -TNF therapy particularly predisposed to ?
Intracellular infections- TB
Can BMT patients receive VZV vaccination ?
No because it is a live virus and they are immunocompromised.
What is the difference in Immunocompromise of solid organ and bone marrow transplant patients ?
BMT patients are the most immunocompromised just before receiving the transplant because their own bone marrow is wiped out. After receiving the transplant a new immune system has to be established from the donors bone marrow.
Solid organ patients are less immunocompromised but then have to suppress their immune system for the rest of their lives.
List different herpes viruses ?
HSV 1 and 2 VZV CMV EBV HHV8 HHV6
Where does VZV lay dormant ?
Dorsal root ganglia
In which cells does CMV lay dormant ?
Monocytes
In which cells does EBV lay dormant ?
B lymphocytes
What is the main treatment for HSV infection ?
Acyclovir
What are 2 treatment/prophylaxis of VZV options for immunocompromised or pregnant women ?
Prophylactic aciclovir
Post-exposure prophylaxis with VZig