Microbiology 22: Opportunistic Viral Infections Flashcards

1
Q

Which 2 organisms can cause Infective mononucleosis ?

A

CMV

EBV

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2
Q

Which genetic mutation gives a predisposition to invasive Herpes simplex encephalitis ?

A

UNC93B

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3
Q

What type of virus is HIV ?

A

Lentivirus

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4
Q

Which cells does HIV target ?

A

CD4+ T cells

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5
Q

Which Virus causes Kaposi Sarcoma ?

A

HHV8

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6
Q

Which virus causes Burkitss lymphoma in HIV patients ?

A

EBV

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7
Q

Which infections are people receiving anti -TNF therapy particularly predisposed to ?

A

Intracellular infections- TB

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8
Q

Can BMT patients receive VZV vaccination ?

A

No because it is a live virus and they are immunocompromised.

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9
Q

What is the difference in Immunocompromise of solid organ and bone marrow transplant patients ?

A

BMT patients are the most immunocompromised just before receiving the transplant because their own bone marrow is wiped out. After receiving the transplant a new immune system has to be established from the donors bone marrow.

Solid organ patients are less immunocompromised but then have to suppress their immune system for the rest of their lives.

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10
Q

List different herpes viruses ?

A
HSV 1 and 2
VZV
CMV
EBV
HHV8
HHV6
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11
Q

Where does VZV lay dormant ?

A

Dorsal root ganglia

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12
Q

In which cells does CMV lay dormant ?

A

Monocytes

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13
Q

In which cells does EBV lay dormant ?

A

B lymphocytes

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14
Q

What is the main treatment for HSV infection ?

A

Acyclovir

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15
Q

What are 2 treatment/prophylaxis of VZV options for immunocompromised or pregnant women ?

A

Prophylactic aciclovir

Post-exposure prophylaxis with VZig

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16
Q

Which virus is associated with Progressive leukoencephalopathy ?

A

JC virus

17
Q

Which virus causes mouth ulcers in post transplant patients ?

A

HSV

18
Q

Which viruses causes a patient to be very unwell and appear septic with high fevers post bone marrow transplant ?

A

Adenovirus

19
Q

What is the typical serology of a patient with chronic hepatitis B infection ?

A

HBs Ag +ve
IgG HBc antibodies +ve
IgM HBc antibodies -ve
HBs antibodies -ve

20
Q

List 2 things that are caused by EBV in HIV patients ?

A

oral hairy leukoplakia

lymphomas: Burkitt’s lymphoma, Hodgkin’s

21
Q

Which disease is caused by EBV in patients post transplant ?

A

post-transplant lymphoproliferative disorder (PTLD)

22
Q

Which virus causes graft rejection ?

A

HHV6