Histopathlogy 5: Connective Tissue Disorders Flashcards
List 3 auto-antibodies seen in SLE ?
Anti-dsDNA
Anti-Smith
Anti-histone (drug related)
What type of hypersensitivity reaction is seen in SLE ?
Type 3 hypersensitivity reaction
What is the HLA association with SLE ?
HLA DR3
Name the heart condition that can be caused by SLE ?
Libman-sack endocarditis
List the signs and symptoms of SLE using the mnemonic SOAP BRAIN MD
Serositis
Oral ulcers
Arthritis
Photosensitivity
Blood disorders- AIHA, ITP Renal involvement - Type 2 RPGN ANA +ve Immune- anti-dsDNA, anti-smith Neuro symptoms Malar rash Discoid rash
Which auto antibodies are seen in Diffuse scleroderma ?
Anti-scl70
Which autoantibodies are seen in limited scleroderma (CREST) ?
Anti-centromere
Which HLA is associated with scleroderma ?
HLA DR5
List the signs and symptoms of limited scleroderma (CREST) ?
Calcinosis Raynauds Esophageal dysmotility Sclerodactily Telangiectasia
No involvement of the trunk
In scleroderma there is increased ……… deposition in the skin causing tight skin
Collagen
Which autoantibodies are seen in Polymyositis and dermatomyositis ?
anti- Jo1
Patient has proximal muscle weakness. Their bloods show increased CK and abnormal EMG. No rash is seen.
Most likely diagnosis?
Polymyositis
Patient has proximal muscle weakness. Their bloods show increased CK and abnormal EMG. A heliotrope rash is seen on the eyelids. There are Gottron papules on the knuckles
Most likely diagnosis?
Dermatomyositis
Japanese lady with absence of pulse and Claudication.
The Rheumatologist says that its a large vessel arthritis.
Most likely diagnosis ?
Takayasu’s arteritis
Elderly man presents with a temporal headache, jaw claudication and scalp tenderness.
Most likely diagnosis?
Temporal arteritis
Large vessel vasculitis