Immuno 9: Immune Modulation Therapies 1 Flashcards
Describe Clonal expansion in T cells?
If an antigen is presented to a T cell receptor which has high specificity for it, the T cell proliferates and differentiates into T helper, Cytotoxic and memory cells
List 3 vaccines given to the elderly aged over 65?
Pneumococcal vaccine (Pneum PPV)
Flu vaccine
Shingles
Describe clonal expansion in B cells ?
If the B cell receptor has high specificity for the antigen presented, the B cell will become activated and undergo proliferation and differentiation into IgM secreting plasma cells and B memory cells
Where do B cells undergo Isotype switching ?
Germinal centres
Where do plasma cells reside ?
Bone marrow
which bacteria is in the BCG vaccine ?
Bovine tuberculosis
Give 3 examples of live attenuated vaccines ?
MMR
Yellow fever
Typhoid
Give 2 examples of Toxoid vaccines (Inactive toxins) ?
Diphtheria
Tetanus
Give 3 examples of subunit vaccines ?
Hep B (HBsAG)
HPV (capsid)
Influenza (HA)
Give one advantage of a life vaccine compared to a component/inactivated vaccine ?
Longer lasting immunity (life long)
Immunity is broader (protects against more strains)
Give an advantage of a component/inactivated vaccine compared to a live vaccine ?
Can be given to immunocompromised patients
Give 3 examples of conjugate vaccines ?
HiB (haemophilus influenza B)
Meningococcus
Pneumococcus
List 2 indications for Haematopoeitic stem cell transplantation ?
SCID
Haematological malignancy
List 3 primary immunodeficiency diseases in which Antibody replacement (pool of antibodies to variety of organisms) is indicated ?
Bruton’s X-linked agammaglobulinaemia
X-linked hyper IgM syndrome
Common variable immunodeficiency
In which 2 Haematological malignancies is Antibody replacement indicated ?
CLL
Multiple myeloma