Chempath 9: Thyroid

Question 1

Which auto-antibodies are seen in Hashimoto’s thyroiditis ?

Answer 1

anti-TPO

also anti-TG

Question 2

Which auto-antibodies are seen in Grave’s disease?

Answer 2

anti-TSH receptor (activates Thyroid production)

Question 3

what is the most common type of thyroid cancer?

Answer 3

Pappilary thyroid cancer

Question 4

In which cancer are Psammoma bodies seen on histology ?

Answer 4

Papillary thyroid

also ovarian serous cyst adenoma

Question 5

which thyroid cancer is associated with MEN2 ?

Answer 5

Medullary thyroid cancer

Question 6

Which thyroid cancer releases calcitonin ?

Answer 6

Medullary thyroid cancer

Question 7

List the 3 cancers seen in MEN1

Answer 7

Pituitary
Parathyroid
Pancreatic (Insulinoma)

3 Ps

Question 8

List the 3 cancers seen in MEN2a

Answer 8

Phaeochromocytoma
Parathyroid
Medullary thyroid

2 Ps 1 M

Question 9

List the 3 cancers seen in MEN2b

Answer 9

Phaeochromocytoma
Medullary thyroid
Mucocutaneous neuromas
1 P 2 Ms

Question 10

What is the mode of inheritance for MEN ?

Answer 10

Autosomal dominant

Question 11

List 2 causes of hyperthyroidism with high iodine uptake ?

Answer 11

Grave’s disease

Multinodular goitre

Question 12

List 2 causes of hyperthyroidism with low iodine uptake ?

Answer 12

De Quervains thyroiditis

Post partum thyroiditis

Question 13

List causes of hypothyroidism ?

Answer 13

Hashimoto's thyroiditis 
Atrophic hypothyroidism 
Iodine deficiency 
post thyroidectomy/Post radioactive iodine 
Drugs- Lithium, Amiodarone

Question 14

Which drug can be used to treat hyperthyroidism without inducing permanent hypothyroidism?

Answer 14

carbimazole