Histopathology 3: Breast pathology Flashcards
45 year old lady presents with thick, white nipple discharge and a periareolar lump. Histology shows distended lactiferous duct.
Most likely diagnosis ?
Mammary duct ectasia
Breastfeeding mother presents with a red, painful, swollen breast. Histology shows neutrophils and pus.
Most likely diagnosis ?
Likely organism ?
Acute mastitis
S.Aureus
60 year old women presents with a painless breast lump. She reports being in a RTA 10 years ago and wonders if the trauma from her seatbelt might have caused it.
Most likely diagnosis ?
Other causes ?
Fat necrosis
Radiotherapy, surgery, panniculitis
A 20 year old lady presents with a breast lump which is well demarcated, mobile and feels rubbery. Histology shows stromal (fibrous tissue) proliferation.
Most likely diagnosis ?
Fibroadenoma
Which breast tumour can originate from Fibroadenomas ?
Phyllodes tumour
A 60 year old lady presents after she noticed her breast lump previously diagnosed as a fibroadenoma has started to increase in size. Histology shows: increased cellularity + Stromal overgrowth and overlapping cells.
most likely diagnosis ?
Phyllodes tumour (Possibly malignant)
Normally phyllodes tumours are benign
45 year old lady presents with bloody nipple discharge. No lump is felt and no mass is seen on mammography.
Histology shows: Large dilated duck with fibrovascular core and stromal vessels.
Most likely diagnosis ?
Duct Papilloma
Histology shows a stellate pattern with central sclerosis surrounded by proliferating glandular tissue.
Most likely diagnosis ?
Radial scar
A 79 year old lady presents with a hard fixed lump of the breast. Paget’s disease of the breast is present and there are signs of nipple retraction.
Most likely diagnosis ?
Breast carcinoma
Paget’s disease of the breast is eczema affecting the nipple
Histology: Intraductal epithelial proliferation, with pleomorphic cells in the duct and necrotic material in the central lumen.
Mammogram: Microcalcifications
Most likely diagnosis ?
DCIS
Young women presents with multiple small lumps in the breast.
Most likely diagnosis ?
Fibrocystic disease
Histology shows linear arrangement of monomorphic cells in a distribution known as the Indian file pattern.
Most likely diagnosis ?
Lobular carcinoma
List 3 receptors tested for in breast carcinoma ?
Oestrogen
Progesteron
HER2
Which drug is used to treat HER2 positive breast carcinoma?
Herceptin
How does the E cadherin help differentiate between invasive ductal and invasive lobular carcinoma ?
If E cadherin +ve = invasive ductal
if E cadherin -ve = Invasive lobular
