Haematology 5: Haematology Of Systemic Disease Flashcards
What is the most common cause of Iron deficiency anaemia ?
Occult blood loss
What do these laboratory findings suggest?
Ferritin: Low
Transferrin saturation: Low
TIBC: High
Iron deficiency anaemia
List 3 features of leucoerythroblastic anaemia of blood film ?
Nucleated red blood cells
Tear drop cells (anisopoikilocytosis)
Immature myelod cells
What is leucoerythroblastic anaemia ?
Anaemia with immature red and white blood cells
Most commonly caused by bone marrow infiltration
List 3 causes of bone marrow infiltration ?
Cancers- Leukaemia/ lymphoma/ myeloma/ solid organ
Myelofibrosis
Severe infection- Miliary TB, Massive fungal infection
List 4 inherited causes of haemolytic anaemia ?
Sickle cell disease
Thalasaemia
G6PD
HS
Which test can be used to diagnose Auto-immune haemolytic anaemia ?
DAT (Coombs’) test
List 2 diseases associated with Auto-immune haemolytic anaemia ?
Lymphoma
SLE
Which cancer type is associated with MAHA ?
Adenocarcinoma
Adenocarcinoma release procoagulant cytokines. This leads to DIC. THis causes a lot of Fibrin strands to form in the micro vasculature. This shears red cells causing them to fragment and undergo haemolysis
Which disease of the returning traveller does not cause neutrophilia ?
Typhoid
What is the difference between reactive neutrophilia and Malignant neutrophilia on blood film ?
Reactive neutrophilia: shows band cells (neutrophils at a later stage of differentiation)
Malignant causes: If Neutrophilia +basophilia + immature myelocytes + Splenomegaly then its likely to be CML
If there is a neutrophilia with Myeloblasts then its likely AML
Which haematological malignancies cause Eosinophilia ?
Hodgkin’s lymphoma
T cell lymphoma
NHL
Which leukaemia has smear cells ?
CLL
