McMurry (Kap 16,0)

Question 1

What are carboxylic acid derivatives?

Answer 1

Carboxylic acid derivatives are organic compounds derived from carboxylic acids (R-COOH) in which the -OH (hydroxyl) group has been replaced by another atom or group of atoms.

Despite the change, these derivatives retain a similar functional group structure where the carbonyl (C=O) is bonded to an electronegative group, giving them characteristic reactivity patterns similar to carboxylic acids.

(you can see the different derivatives on page 555)

Another way to describe a carboxylic acid derivatives are compounds in which an acyl group (COR) is bonded to an electronegative atom or substituent that can act as a leaving group in a nucleophilic acyl substitution reaction.

Question 2

Carboxylic acid derivatives are among the most widely occuring of all molecules.

What are their primary reaction?

Answer 2

Nucleophilic acyl substitution - is one of the four fundemental carbonyl group processing.

“Carbonyl group processing” refers to chemical reactions and transformations involving a carbonyl group (C=O).