manipulating cardiovascular function Flashcards
1
Q
where are the adrenergic receptors located in the cardiovascular system
A
in the heart: sympathetic nervous system control
2
Q
where are the cholinergic receptors located in the cardiovascular system
A
in the heart: parasympathetic NS control
3
Q
how do agonists stimulate receptor response
A
- binding leads to biological response depending on receptor type and receptor localisation
- magnitude of response is determined by the dose and the drug (selective vs. non-selective)
4
Q
describe competitive antagonsists
A
- bind to receptor in the agonist binding pocket
- surmountable (if you add aneough agonist the antagonist can be overridden)
- reversible
- easier to develop antagonsists than agonsists
5
Q
what is the effect of an antagonists on a dose repsonse curve
A
specific antagonists cause parallel right shifts to the dose curve indiczting competitive antagonist
