Lecture Notes exam 2 Flashcards
Sexual Reproduction
offspring arise from two parents and a mixture of genes are inherited from both, offsprings will have better chance of survival of effects of mutations
Asexual Reproduction
produces genetically identical copies of a single parent (clones)
Mitosis
somatic cells, purpose of growth, repair and replace, diploid to diploid
Meiosis
division of specialized cells that form reproductive cells known as gametes. A diploid cell into 4 haploid gametes. Nuclear division, halves chromosome number
2 Haploid Gametes fuse to produce
zygote
Zygotes are
diploid 2n
Gametes do not__, they ___
divide, produced by germ cells by meiosis
How many chromosomes in human somatic cell and how many pairs
46;23
Mitosis ___ chromosome number. Meiosis ___ chromosome number
maintain; reduce.
Haploid
single set of chromosome (n)
Diploid
double set of Chromosome (2n)
Genes
regions in an oragnism’s DNA that encode information about heritable traits. Pairs on homologous chromosomes.
Alleles
Different versions of the same gene.
DNA is replicated
Once
Meiosis 1
Diploid germ cell replicated its chromosome and form tetrad (pairs of duplicated homologous chromosomes); each duplicated homologous chromosome is separated from its partner
Meiosis II
two haploid cells cells divide, sister chromatids are separated (like in mitosis)
Stages of Meiosis I
Prophase: homologous chromosomes condense, pair up, and swap segments. Aka crossover stage
Metaphase: Chromosomes line up
Anaphase: Chromosomes separate
Telophase: A new nuclear envelope cause so two haploid nuclei form.
Stages of Meiosis II
Prophase II: the chromosomes condenses with no dna replication
Metaphase II: chromosomes align
Anaphase II: Sister chromatids separate
Telophase II: 4 haploid cells
Crossover
happens in proffer I, helps with genetic variability. mixture of both parents.
random assortment produces
2^23 possible combinations of homologous chromosome
Sporophytes
Diploid bodies with specialized structures that form spores (haploid cells) that give rise to gametophytes through mitosis
Gametophytes
A multi-celled haploid body inside which on ore more gametes form
fertilization
fusion of two haploid gametes (sperm and egg) resulting in a diploid zygote
Genes occur in pairs of
homologous chromosomes
Gregor Mendel
Breeding garden pea plants
Characters
heritable features that vary among individuals
Traits
variants for a character
Genes
Discrete heritable units of information for traits
Alleles
Alternative forms of a gene
Each gene has a specific ___on a chromosome
locus
How many chromosomes do diploid cells have
2 pairs of homologous chromosomes
Genotype
Particular set of allies that an individual carries
Bb, BB, bb
Homozygous
Two identical alleles of a gene is homozygous for that gene
Heterozygous
An individual with non-identical alleles of a gene
Phenotype
Observable traits such as color
Mutated genes are
new alleles whether or not it affects a phenotype
True breeding
individual that is homozygous for a particular trait; the same trait is produced over many generations. AA or aa
Hybrid
the heterozygote offspring of a cross between two individuals that breed true for different forms of a trait. Aa
Dominant and Recessive Alleles
Dominant is shown in a heterozygote phenotype and recessive is not
Genotypes of :
Homozygous dominant
Heterozygous
Homozygous recessive
AA; Aa; aa and they only have 2 phenotypes
Probability
A measure of the chance that a particular outcome will occur
Punnett square
a grid used to calculate the probability of genotypes and phenotypes among offspring of various crosses
Testcross
method of determine if an individual is heterozygous or homozygous dominant (BB x bb)
Monohybrid Cross
between two individuals that are heterozygous for a certain character. crossing of two true-breeding individuals resulting in heterozygote offspring and they are hybrids which are represented in the first filial generation. Then those hybrids are crossed with each other to produce the second filial generation
Mendel’s Law of Segregation
Differing traits in organisms result from pairs of genetic factors that separate during gamete formation such that each gamete receives only one of the two factors.
Dihybrid
16 results of genotypes, and phenotype ratio is 9:3:3:1
Mendel’s Law of Independent Assortment
during gamete formation, members of one pair of ‘genetic factors’ are distributed into gametes independently of other pair
Law of Segregation Modern
Different traits are the result of the separation of pairs of alleles on homologous chromosomes into discrete gametes during meiosis
Law of Independent Assortment Modern
Each pair of alleles is sorted into gametes independently of other pairs during meiosis; we now know that this law applies when the genes are located on different pairs of homologous chromosomes
Linkage group
all genes on one chromosome
genes are passed on together
Linked genes
very close together; crossing over rarely occurs between them
Codominance
two non-identical alleles of a gene are both fully expressed in heterozygotes, so neither is dominant or recessive
Multiple Allele System
genes with three or more alleles in a population
ex. blood types
Incomplete Dominance
one allele is not fully dominant over its partner, and the heterozygous offspring is a mix
Epistasis
Two or more gene products influence a trait, one gene product suppresses the effect of another (dog color)
Bell Curve
When continuous phenotypes are divided into categories and plotted as a bar chart.
genotype + environment=
phenotype
Are phenotypes qualitative
yes
Mendelian Genetics
Characters are controlled by a single gene
Alleles exhibit a complete dominance relationship
Phenotypes are qualitative
Pleiotropy
Single gene affecting many traits
Epigenetics
heritable changes NOT caused by change in DNA sequence
Genetic abnormalities
rare version of trait, not life-threateneing
Genetic disorder
does cause health problems, may be life threatening
Geneticists
study inheritance pattern in humans by tracking these genetic abnormalities and disorders through families
Pedigree
used to determine the probability that future offspring will be affected by a genetic abnormality or disorder
An allele is inherited in an autosomal dominant pattern if
if the trait it specifies appears in people with homozygous dominant and heterozygous genotypes
An allele is inherited in an autosomal recessive pattern if
if the trait it specifies appears only in people with homozygous recessive genotypes
Achondroplasia
Homozygous dominant individuals do not survive long enough to reproduce
Huntington’s Disease
Symptoms often do not develop until after 30 years of age
An affected individual may have already passed on the allele to offspring
Hutchinson-Gilford Progeria
Most individuals with this disease do not survive long enough to reproduce
Autosomal Recessive Inheritance
Skips generations, two recessive alleles, so heterozygotes do not have trait.
Albinism
Depending on which gene(s) are affected, absence or low levels of melanin may affect pigmentation of skin, hair, eyes
Autosomes and Sex Chromosomes pairs
22 pairs of autosomes(homologous) and 1 pair of sex chromosomes (non-homologs)
X-linked Disorders
inherit in a recessive pattern because dominant X chromosomes tend to be lethal in male embryos, only homozygous females have this disorder.
an ex. is color blindness
all new alleles arise by
mutation
duplication
DNA sequence that are repeated two or more times, duplication may be caused by unequal crossover in prophase
Deletion
Loss of some portion of a chromosome, usually causes serious or lethal disorders
Inversion
Part of the sequence of DNA becomes oriented in the reverse direction with no molecular loss
Translocation
If chromosome breaks, the broken part may get attached to a different chromosome, or to a different part of the same one.
Polyploid
they have three or more complete sets of chromosomes
Trisomy 21
down syndrome
Karyotype
arrangement of chromosome in pairs 23
Changes in sex chromosome number may
impair learning or motor skills or be undetected
Stem Cells
divide to produce more stem cells
OR
differentiate into specialized cells
Totipotent
embryonic stem cells develop into a individual
Embryonic Stem Cells (hESCs)
hold the potential to repair tissues that are normally not regenerated in the adult body
Cell Junctions
Connects cells, tights junctions (prevent fluid movement between cells), gap junctions(channel connects cytoplasm between cells) and adhering junctions(connect cels together)
Hierarchical Level
Atoms Molecules Organelles Cells Tissues Organs Organ System Organism
Epithelial tissue
covers body surfaces and lines the internal cavities such as the gut
connective tissue
holds body parts together and provides structural support
Muscle tissue
moves the body or its parts
Nervous tissue
detects stimuli and relays signals
extracellular fluid
surrounds cells, provides them with nutrients, and collects cellular waste
Plasma
fluid portion of blood
Generation evolution genes
genes that will best help an individual survive and reproduce in their environment are preferentially passed on
Diffusion is only efficient through
short distances
Evolution modifies
existing structures
Epithelium (epithelial tissue)
A sheet of cells that covers the body’s outer surface and lines internal ducts and cavities
Basement membrane
A layer of ECM (extracellular matrix) that is synthesized and secreted by the cells themselves
Simple squamous epithelium
lines blood vessels, the heart, and air sacs of lungs. allows substances to cross by diffusion
simple cuboidal epithelium
lines kidney tubules, ducts of some glands, reproductive tract. Functions in absorption and secretion, movement of materials
simple columnar epithelium
lines some airways, part of the gut. Functions in absorption and secretion, protection.