Lecture 4: Anti-Fungal Agents Flashcards
____ is used to treat superficial infections
A. Ketoconazole
B. Miconazole
C. Fluconazole
D. Griseofulvin
D. Griseofulvin
Which four anti-fungal drugs are used to treat systemic, subcutaneous fungal infections?
Keto/Mico/Fulco/Itra-conazole
What type of therapy is indicated for patients who are febrile, neutropenic and do NOT responds to broad spectrum antibacterial treatment? Which broad-spectrum anti-fungal drugs should be used?
Empiric Anti-Fungal Therapy
1. Miconazole
2. Amphotericin B
Prophylactic Antifungal therapy is commonly used in which patient populations?
A. Immunocompromised
B. Immunocompetent
A. Immunocompromised
What are the two major groups of -azoles?
Imidazole
Triazoles
Which three drugs can be used to treat mild to moderate Tinea infections?
Clotrimazole
Miconazole
Tolnaftate
Which five drugs are used to treat moderate-severe Tinea infections?
Ketoconazole
Miconazole
Fluconazole
Itraconazole
Terbinafine
Which two drugs can be used to treat severe Tinea infections?
Griseofulvin and Ketoconazole
True or False: Drugs that end in -azole can be used to treat Tinea Versicolor
True
The -azoles, Nystatin, Terbinafine and Amphotericin B are used to treat:
A. Candidiasis
B. Tinea Versicolor
C. Dermatitis
A. Candidiasis
Amphotericin B and Nystatin affects:
A. Ergosterol Synthesis
B. Cell wall Synthesis
C. Nuclear Division
D. Membrane Function
D. Membrane Function
Azoles affects:
A. Ergosterol Synthesis
B. Cell wall Synthesis
C. Nuclear Division
D. Membrane Function
A. Ergosterol Synthesis
Griseofulvin affects:
A. Ergosterol Synthesis
B. Cell wall Synthesis
C. Nuclear Division
D. Membrane Function
C. Nuclear Division
Echinocandins affect:
A. Ergosterol Synthesis
B. Cell wall Synthesis
C. Nuclear Division
D. Membrane Function
B. Cell wall Synthesis
Squalene, a precursor sterol, is converted to lanosterol via:
Squalene monooxygenase
Which two molecules inhibit Squalene Monooxygenase?
Terbinafine and Tolnaftate
- Accumulation of squalene
The -azoles inhibit this enzyme:
A. Squalene monooxygenase
B. 14-a demethylase (P450)
B. 14-a demethylase (P450)
- Accumulation of lanosterol
Which enzyme converts lanosterol to ergosterol?
A. Squalene monooxygenase
B. 14-a demethylase (P450)
B. 14-a demethylase (P450)