L28: Fluroquinolones Flashcards
All the drugs that end in -floxacin belong to which drug class?
Fluroquinolones
True or False: Fluroquinolones are no longer agents for routine infections
True
____, a 5th gen fluroquinolones, has activity against MRSA
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin
B. Delafloxacin
___, a 3rd gen fluroquinolone, is active against strep and atypicals (less so w/pseudomonas)
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin
C. Levofloxacin
Which 4th generation fluroqunilone is active against anaerobes, aerobic gram (+) and (-) organisms??
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin
A. Moxifloxacin
Which 2nd gen fluroqunolone is good for systemic infections and is active against psuedomonas?
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin
D. Ciprofloxacin
D. Ciprofloxacin
What do Fluroqunolones target?
Bacterial DNA enzymes
1) DNA Gyrase
2) DNA Topoisomerase IV
For Fluroqunolones, gyrase is the ____ target while Topo IV is the _____ target
A. gram (-) and gram (+)
B. gram (+) and gram (-)
A. gram (-) and gram (+)
True or False: Fluroquinolones are bactericidal and concentration dependent
True
____ proteins are 1/4 modes of fluroquinolone resistance
Qnr
Fluroquinolones binds ___ metals. However, poor CSF penetration.
polyvalent
Gatifloxacin is only administered via _____
A. opthalamic
B. oral
C. IV
A. opthalamic
Which of the following is only excreted via liver?
A. Ofloxacin
B. Gatifloxacin
C. Levofloxacin
D. Cipro
E. Moxifloxacin
E. Moxifloxacin
Cipro and Levofloxacin are 2nd and 3rd generation fluroquinolones that are excellent at attacking gram ___
A. gram (+)
B. gram (-)
B. gram (-)
Cipro and Levo are good for MSSA but not for ____
MRSA/ORSA
Which of the following works best for gram (-) like P. aeruginosa?
A. Cipro
B. Levofloxacin
A. Cipro
___ and ___ are 3rd / 4th gen respiratory fluroqinolones
Levo and Moxi
Which 3rd/4th gen respiratory fluro has modest activity against anaerobes, but does not work for P. aeruginosa?
Moxi
Why is the 4th gen Gatifloxacin no longer available for systemic therapy?
Hypoglycemia AE
Uses for Delafloxacin (5th gen)???
- P. aero
- Gram (-)
- MRSA/ORSA
True or False: Fluros can be used against Pseudomonas in CF – for acute exacerbation
True
True or False: Fluros can be given for N. gonorrhoeae
False - no longer due to resistance
True or False: Fluros induce shiga toxin gene
True
Which bone, joint tissue infections can fluros treat?
- chronic OM
- diabetic foot infections
True or False: Fluros are good for multi-drug resistant Tb and HIV, as well as anthrax infection
True
Which fluro is associated with C.dif?
Which is associated with CNS disturbance?
Cipro
Moxi
True or False: Nausea, and peripheral neuropathy are common AE associated with fluros
True
All of the fluros can cause QT elongation exceot
Delafloxacin
Why can fluros increase chance of having a seizure?
Antagonize GABA-A
What are fluros BBW for?
Chondrotoxicity
- tendon rupture
True or False: Fluros inhibit bacterial DNA synthesis (DNA gyrase and Topoisomerase IV)
True
