L28: Fluroquinolones

Question 1

All the drugs that end in -floxacin belong to which drug class?

Answer 1

Fluroquinolones

Question 2

True or False: Fluroquinolones are no longer agents for routine infections

Answer 2

True

Question 3

____, a 5th gen fluroquinolones, has activity against MRSA
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin

Answer 3

B. Delafloxacin

Question 4

___, a 3rd gen fluroquinolone, is active against strep and atypicals (less so w/pseudomonas)
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin

Answer 4

C. Levofloxacin

Question 5

Which 4th generation fluroqunilone is active against anaerobes, aerobic gram (+) and (-) organisms??
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin

Answer 5

A. Moxifloxacin

Question 6

Which 2nd gen fluroqunolone is good for systemic infections and is active against psuedomonas?
A. Moxifloxacin
B. Delafloxacin
C. Levofloxacin
D. Ciprofloxacin

Answer 6

D. Ciprofloxacin

Question 7

What do Fluroqunolones target?

Answer 7

Bacterial DNA enzymes
1) DNA Gyrase
2) DNA Topoisomerase IV

Question 8

For Fluroqunolones, gyrase is the ____ target while Topo IV is the _____ target
A. gram (-) and gram (+)
B. gram (+) and gram (-)

Answer 8

A. gram (-) and gram (+)

Question 9

True or False: Fluroquinolones are bactericidal and concentration dependent

Answer 9

True

Question 10

____ proteins are 1/4 modes of fluroquinolone resistance

Answer 10

Qnr

Question 11

Fluroquinolones binds ___ metals. However, poor CSF penetration.

Answer 11

polyvalent

Question 12

Gatifloxacin is only administered via _____
A. opthalamic
B. oral
C. IV

Answer 12

A. opthalamic

Question 13

Which of the following is only excreted via liver?
A. Ofloxacin
B. Gatifloxacin
C. Levofloxacin
D. Cipro
E. Moxifloxacin

Answer 13

E. Moxifloxacin

Question 14

Cipro and Levofloxacin are 2nd and 3rd generation fluroquinolones that are excellent at attacking gram ___
A. gram (+)
B. gram (-)

Answer 14

B. gram (-)

Question 15

Cipro and Levo are good for MSSA but not for ____

Answer 15

MRSA/ORSA

Question 16

Which of the following works best for gram (-) like P. aeruginosa?
A. Cipro
B. Levofloxacin

Answer 16

A. Cipro

Question 17

___ and ___ are 3rd / 4th gen respiratory fluroqinolones

Answer 17

Levo and Moxi

Question 18

Which 3rd/4th gen respiratory fluro has modest activity against anaerobes, but does not work for P. aeruginosa?

Answer 18

Moxi

Question 19

Why is the 4th gen Gatifloxacin no longer available for systemic therapy?

Answer 19

Hypoglycemia AE

Question 20

Uses for Delafloxacin (5th gen)???

Answer 20

• P. aero
• Gram (-)
• MRSA/ORSA

Question 21

True or False: Fluros can be used against Pseudomonas in CF – for acute exacerbation

Answer 21

True

Question 22

True or False: Fluros can be given for N. gonorrhoeae

Answer 22

False - no longer due to resistance

Question 23

True or False: Fluros induce shiga toxin gene

Answer 23

True

Question 24

Which bone, joint tissue infections can fluros treat?

Answer 24

1. chronic OM
2. diabetic foot infections

Question 25

True or False: Fluros are good for multi-drug resistant Tb and HIV, as well as anthrax infection

Answer 25

True

Question 26

Which fluro is associated with C.dif?

Which is associated with CNS disturbance?

Answer 26

Cipro
Moxi

Question 27

True or False: Nausea, and peripheral neuropathy are common AE associated with fluros

Answer 27

True

Question 28

All of the fluros can cause QT elongation exceot

Answer 28

Delafloxacin

Question 29

Why can fluros increase chance of having a seizure?

Answer 29

Antagonize GABA-A

Question 30

What are fluros BBW for?

Answer 30

Chondrotoxicity
- tendon rupture

Question 31

True or False: Fluros inhibit bacterial DNA synthesis (DNA gyrase and Topoisomerase IV)

Answer 31

True