L14: Medical Marujana

Question 1

What is the main psychoactive component of marijuana?

Answer 1

THC (delta 9 - tetrahydrocannabinol)

Question 2

True or False: CBD does not produce a high and is regulated separately from THC

Answer 2

True

Question 3

What is Epidolex?

Answer 3

CBD product approved in US for childhood epilepsy (Lennox-Gastaut and Dravet Syndrome)

Question 4

True or False: Delta-8 THC has similar effects as THC, but psychiatric effects are worse

Answer 4

True

Question 5

True or False: THC-O Acetate has stronger psychoactive effects than THC

Answer 5

True

Question 6

Why is TCH able to be rapidly absorbed from the lungs and distributed to the brain and other fatty tissue?

Answer 6

Very lipid soluble

Question 7

True or False: Due to its high lipid solubility, THC accumulates in fat and can be released slowly over time

Answer 7

True

Question 8

Where are cannabinoid receptors found?
A. PNS
B. CNS
C. Lateral Geniculate

Answer 8

B. CNS

Question 9

Which endogenous compound acts on cannabinoid receptors in the CNS?
A. Arachidionic acid
B. Anandamide
C. THC

Answer 9

B. Anandamide (AA analog)

Question 10

What are the two different types of endocannabinoid receptors? Where are they found and what is their function?

Answer 10

1) CB1: CNS, mediates CNS effects

2) CB2: Peripheral, mediates immune effects

Question 11

Where in the CNS are CB1 receptors abundant?

Answer 11

1. Frontal cortex
2. Basal ganglia
3. Limbic system

Question 12

True or False: Endocannabinoids, made on demand in stimulated PS cells, appear to function as a negative feedback system to limit further pre-synaptic transmitter release

Answer 12

True

Question 13

Endocannabinoids and cannabinoid receptors modulate ___, ___, ___, and ___

Answer 13

pain, appetite, mood, memory, motor/immune function

Question 14

The relaxation (high) and sedation/sleepyness (stoned) that one feels after smoking weed is due to effects on which receptor?
A. CB1
B. CB2

Answer 14

A. CB1

Question 15

True or False: High doses of marijuana can cause hallucinations, paranoid, and increased appetite

Answer 15

True

Question 16

Tachycardia, postural hypotension, and reddening of eyes are effects of smoking weed

Answer 16

True

Question 17

True or False: Marijuana decreases IO pressure, but only at very high doses

Answer 17

True

Question 18

If one’s immune system is suppressed after smoking weed, it is most likely related to which receptor?

Answer 18

CB2-Receptor

Question 19

True or False: Nystagmus, ptosis, photphobia, decreased tears, and redness of conjunctiva are ocular effects of smoking weed

Answer 19

True

Question 20

_____: Associated with high dose, daily use of cannabinoids. Main symptom: severe vomiting that is refractory to anti-emetics drugs

Answer 20

Cannabinoid Hyperemesis Syndrome

Question 21

True or False: Marijuana produces some degree of tolerance with chronic use and, if used regularly, can result in physical dependence

Answer 21

True

Question 22

____ is approved for nausea in cancer chemotherapy and preventing cachexia in AIDS patients

Answer 22

Dronabinol

Question 23

True or False: Law in IL for medical weed did not include chronic pain as a qualifying condition

Answer 23

True

Question 24

Can a doctor prescribe medical marijuana?

Answer 24

No - they can recommend or certify it, but patient has to get user card

Question 25

Pros and cons of smoking weed?

Answer 25

Pros
- easy to titrate dose

Cons
- healthy risks
- fires

Question 26

True or False: It is easier to overdose with edible forms of weed and there’s often delayed effects

Answer 26

True

Question 27

Smoking has ___ absorption while eating weed has ___ absorption / ___ titration of the dose

Answer 27

rapid; slow; poor