L14: Medical Marujana Flashcards
What is the main psychoactive component of marijuana?
THC (delta 9 - tetrahydrocannabinol)
True or False: CBD does not produce a high and is regulated separately from THC
True
What is Epidolex?
CBD product approved in US for childhood epilepsy (Lennox-Gastaut and Dravet Syndrome)
True or False: Delta-8 THC has similar effects as THC, but psychiatric effects are worse
True
True or False: THC-O Acetate has stronger psychoactive effects than THC
True
Why is TCH able to be rapidly absorbed from the lungs and distributed to the brain and other fatty tissue?
Very lipid soluble
True or False: Due to its high lipid solubility, THC accumulates in fat and can be released slowly over time
True
Where are cannabinoid receptors found?
A. PNS
B. CNS
C. Lateral Geniculate
B. CNS
Which endogenous compound acts on cannabinoid receptors in the CNS?
A. Arachidionic acid
B. Anandamide
C. THC
B. Anandamide (AA analog)
What are the two different types of endocannabinoid receptors? Where are they found and what is their function?
1) CB1: CNS, mediates CNS effects
2) CB2: Peripheral, mediates immune effects
Where in the CNS are CB1 receptors abundant?
- Frontal cortex
- Basal ganglia
- Limbic system
True or False: Endocannabinoids, made on demand in stimulated PS cells, appear to function as a negative feedback system to limit further pre-synaptic transmitter release
True
Endocannabinoids and cannabinoid receptors modulate ___, ___, ___, and ___
pain, appetite, mood, memory, motor/immune function
The relaxation (high) and sedation/sleepyness (stoned) that one feels after smoking weed is due to effects on which receptor?
A. CB1
B. CB2
A. CB1
True or False: High doses of marijuana can cause hallucinations, paranoid, and increased appetite
True
Tachycardia, postural hypotension, and reddening of eyes are effects of smoking weed
True
True or False: Marijuana decreases IO pressure, but only at very high doses
True
If one’s immune system is suppressed after smoking weed, it is most likely related to which receptor?
CB2-Receptor
True or False: Nystagmus, ptosis, photphobia, decreased tears, and redness of conjunctiva are ocular effects of smoking weed
True
_____: Associated with high dose, daily use of cannabinoids. Main symptom: severe vomiting that is refractory to anti-emetics drugs
Cannabinoid Hyperemesis Syndrome
True or False: Marijuana produces some degree of tolerance with chronic use and, if used regularly, can result in physical dependence
True
____ is approved for nausea in cancer chemotherapy and preventing cachexia in AIDS patients
Dronabinol
True or False: Law in IL for medical weed did not include chronic pain as a qualifying condition
True
Can a doctor prescribe medical marijuana?
No - they can recommend or certify it, but patient has to get user card
Pros and cons of smoking weed?
Pros
- easy to titrate dose
Cons
- healthy risks
- fires
True or False: It is easier to overdose with edible forms of weed and there’s often delayed effects
True
Smoking has ___ absorption while eating weed has ___ absorption / ___ titration of the dose
rapid; slow; poor
