Lecture 27- Cannabis and Hallucinogens Flashcards
Cannabis medical use history
- historically used to treat many ailments
- marijuana is a schedule 1 drug- prohibited from medical use
- spurred by use of marijuana in AIDS patients (reduces vomiting and stimulates appetite)- cannabis clubs were organizations that purchase bulk marijuna and sell/give away to patients
cannabis medical uses- cancer
- nausea/vomiting, pain
- downside is the mental effects- disorienting/uncomfortable
cannabis medical uses- glaucoma (intra-ocular pressure)
- weed reduces pressure but…
- weed may reduce blood flow to optic nerve and has side-effects
- developing synthetics and/or topical application to reduce side-effects
- experts believe that non-THC meds may have greater benefits
cannabis medical uses- cachexia (wasting away syndrome)
stimulates appetite
cannabis medical uses-other
- potential treatment of numerous disorders/diseases
- chronic pain, epilepsy, hypertension, asthma, anxiety, Alzheimer’s depression, etc
legalization
debate over medical legalization likely will continue for some time, synthetics may be the solution
what schedule are synthetic cannabinoids?
3 (medical use allowed)
Marinol (dronabinol) and Cesamet
synthetic weed used for anti-nausea (for cancer patients)
synthetics
sativex
oral spray, painkiller for MS and rheumatoid arthritis
synthetics
rimonabant
- inverse agonist
- obesity and alzheimers
What are the benefits of synthetics?
- they target specific receptors (CB1 or CB2)
- so, they only produce the wated effect without side effects
What is the downside of synthetics
effects are slow because of formulation (oral)
Dose CBD make THC safer?
- PANSS- positive and negative syndrome scale measures severity of psychotic symptoms (adverse effects of thc)
- least score with largest cbd to thc ratio
What are hallucinogens?
- drugs that radically change a person’s mental state by distorting the perception of reality, in some cases to the point of hallucinations
- illusionogenic, psychomimetic, psychedelic, and mind expanding
Serotonergic hallucinogens list
LSD, mescaline, and psilocybin
Methylated amphetamines list
MDA and MDMA (esctasy)