lecture 14 Flashcards
Where does Pyruvate oxidation and citric acid cycle occur?
mitochondrial matrix
Where does electron transport and oxidative phosphorylation occur?
mitochondrial inner membrane
What happen to pyruvate in the presence of O2?
it enters mitochondria and is oxidized by a multi-subunit complex
How is glycolysis linked to the citric acid cycle?
glycolysis generates pyruvate and it is then converted to acetyl coenzyme (acetyl CoA) which starts the citric acid cycle
What is the yield of the citric acid cycle?
Per acetyl-CoA you get:
-2 Co2
-3 NADH
- 1FADH2
-1 ATP by substrate-level phosphorylation
Who? Deduced that the P:O ratio was 3:1 in heart muscles.
Severo Ochoa
Who? Worked on Krebs cycle enzymes.
Severo Ochoa
Who? Nobel prize with Arthur Komberg in 1959 for the discovery of an RNA metabolizing enzyme important for replication of RNA viruses
Severo Ochoa
Who? Contributed to deciphering the genetic code.
Severo Ochoa
What accounts for most of the energy from food?
NADH and FADH2
Where is the the electron transport chain?
inner membrane of the mitochondria
What is cristae?
folds or infoldings of the inner mitochondrial membrane
What is most of the electron transport chain made of?
proteins that exist in multiprotein complexes
What is chemiosmosis?
the use of energy in a H+ gradient to drive cellular work
What is ATP synthase?
a protein complex
