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Advanced Pharm > Immuno, Arthritis > Flashcards

Immuno, Arthritis Flashcards

Exam 2

1
Q

What are the components of the immune system?

A

innate and adaptive

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2
Q

What are the two key problems with immunosuppression?

A

opportunistic infections, increased cancer risk

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3
Q

This allergic response causes acute symptoms but gives defense against parasites.

A

mast cell degranulation

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4
Q

What are other uses of first generation of antihistamines?

A

prevent motion sickness/vertigo, sedation/hypnosis, antiemetic

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5
Q

Problems with antihistamines

A

sedation, dry mouth, tachy, HTN

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6
Q

This antimetabolites is used for organ transplants, RA and can cause opportunistic infections and sepsis

A

mycophenolate mofetil

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7
Q

This is an excessive release of cytokines

A

cytokine storm

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8
Q

This cytokine inhibitor is used in organ transplants and RA, danger is nephrotoxicity

A

cyclosporine

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9
Q

This cytokine inhibitor is more effective than cyclosporine but is also more toxic, danger are kidney and neuro toxicities

A

tacrolimus

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10
Q

This cytokine inhibitor is used in graft vs. host infections, may cause hyperlipidemia

A

sirolimus

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11
Q

These 1st generation antihistamine are readily available over the counter

A

Chlorpheniramine, diphenhyrdramine, doxylamine

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12
Q

This immuno-antibody drug is prepared from murine or equine sources, infused slowly, and repetitive use can cause antibody response in pt.

A

antithymocyte globulins

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13
Q

This immuno-antibody is pooled immunoglobulins from 1000s of donors, effects last 2-3 mos.

A

IVIG

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14
Q

This immuno-antibody is derived from mice and antibodies produced bind to any targeted molecule

A

Monoclonal Antibodies

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15
Q

What is Omalizumab used for?

A

Pt with severe asthma

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16
Q

Monoclonal antibody against HER-2

A

Trastuzumab

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17
Q

suffix for monoclonal antibody

18
Q

prefix for monoclonal antibody

A

dealers choice except Muro

19
Q 
infix target of -mabs:
tumor
Circulation
neural
immune
A
  • tu-
  • ci- or -cir-
  • neu-
  • li- or -lim-
20
Q

infix type of -mabs:
chimeric
humanized

21
Q

interlukin-2 receptor blocerks

A

Basiliximab, daclizumab

22
Q

depletion of t lymphocyte drugs

A

alemtuzumab

23
Q

tumor necrosis factor-alpha blockers

A

infliximab and adlimumab

24
Q

Glucocorticoids used for RA giving symptom relief but can lead to long term toxicity

A

Prednisone, methylprednisolone

25
Q

Gold sodium thiomalate, aurothioglucose, Auranofin are types of

A

gold salts

26
Q

Gold adversities and tx

A

dermatitis, proteinuria, blood dyscrasis

tx: stop tx, halflife awareness, Dimercaprol

27
Q

This antimalarial agent used in RA can cause GI upset and exacerbate gold related dermatitis

A

Chloroquine

28
Q

Major Chloroquine concerns (2)

A
  1. retinopathy

2. cardiac conduction disturbances

29
Q

This RA drug is quite toxic and is reserved for difficult cases

A

D-Penicillamine

30
Q

This immunosuppressive DMARD is an antimetabolite and antifolate sensitive on rapid dividing cells used in cancer, severe psoriasis, early pregnancy termination

A

Methotrexate

31
Q

What are 3 of methotrexate’s toxicities?

A

liver, bone marrow suppression, mucosal ulceration

32
Q

This immunosuppressive DMARD slows lymphocyte mitosis, reduces pain and swelling, reduces disease progression

A

Leflunomide

33
Q

This TNF receptor mediates autoimmune related inflammation

34
Q

This is a TNF receptor seen in infection & tumor surveillance function

35
Q

3 TNF-alpha blockers

A

Adalimumab, Etanercept, Infliximab

36
Q

This TNF-alpha blocker is used when all else has failed

A

Etanercept

37
Q

Etanercept adversity and long term safety issues

A

injection site irritation; infections, neoplasms

38
Q

This is a chimeric IgG, monoclonal against TNF_alpha, used in Crohns for 6 wks

A

Infliximab

39
Q

These drugs block uric acid production

A

allopurinol, febuxostat

40
Q

This drug is anti-inflammatory effects reducing pain in 12-24 hrs but can cause diarrhea and is being replaced by NSAIDS

A

Colchicine

41
Q

What drug needs avoided with Colchicine?

A

Aspirin, Macrolide Abx

42
Q

These uricosuric agents block uric acid reabsorption from proximal tubules and is well tolerated with some GI upset

A

Probenecid, sulfinpyrazone

Advanced Pharm (23 decks)

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