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Advanced Pharm > GI Flashcards > Flashcards

GI Flashcards

GI Review

1
Q

Peptic ulcer recurrent rates

A

85% if H. pylori not removed, 5-15% recurrence if it is removed

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2
Q

bismuth, metronidazole, tetracycline, PPI

A

Quadruple H. pylori Tx

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3
Q

PPI, amoxicillin or metronidazole, clarithromycin

A

Triple regiment

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4
Q

worsening dementia symptoms

A

anticholinergic drugs like Dicyclomine (Bentyl) can cause

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5
Q

H1

A

mediate allergic responses

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6
Q

H2

A

stimulate gastric acid secretion

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7
Q

H3

A

CNS neurotransmission

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8
Q

H4

A

mast cell chemotaxis

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9
Q

Cimitidine, Ranitidine, Nizatidine, Famotidine

A

H2s from lowest to highest

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10
Q

inhibits CYP 450

A

Cimetidine drug interactions

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11
Q

PPI

A

most powerful HCI secretion suppressors

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12
Q

C. diff, low levels of magnesium, osteoporosis, cv disease

A

Long term PPI issues

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13
Q

suppress acid production, stimulate mucin production, increase bicarb, increase mucosal blood flow

A

gastric effects of prostaglandins

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14
Q

misoprostol

A

prostaglandin agonist contraindicated in pregnancy

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15
Q

aluminum hydroxide, magnesium hydroxide, calcium carbonate

A

antacid tablets

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16
Q

renal failure

A

antacid tablets are contraindicated in ___

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17
Q

loperamide

A

opiate analog with an anticholingeric effects can cause toxicmegacolon in kids and avoid use in severe colitis

18
Q

largely protective (4) things: suppress acid production, stimulate mucin, increase bicarb, increase mucosal blood flow

A

action of gastric prostaglandins

19
Q

metabolic alkalosis

A

why do you not use bicarb in neutralizing acid?

20
Q

mucusal protectants, 1 hr before

A

sucralfate, bismuth and how to take

21
Q

Phenothiazine, Substituted Benzamides, Butyrophenones, Benzo, Cortosteroids, Cannabinoid Receptor Agonsist, Serotonin,Sustance P

A

anti-emetics

22
Q

prolonged QT interval

A

What is the most concerning anti-serotonin side effect?

23
Q

appetite suppression and weight loss

A

amphetamine side effects

24
Q

high body temperature

A

serontonin syndrome main symptom

25
Q

autonomic nervous system

A

involuntary, unconscious nervous system

26
Q

atonic colon

A

what is the most concerning irritant/stimulant laxative side effect

27
Q

colloids, saline cathartics; water retention and intestinal distention

A

what are the types of bulking agents and how do they work?

28
Q

chloride channel activators

A

prostaglandin derivative that stimulates intestinal fluid secretaions; used in chronic constipation and IBS w/ constipation

29
Q

antimotility agents and absorbents

A

antidiarrheal drug classes

30
Q

near 4th ventricle outside of BB barrier, medulla, afferents, cortex inpus, peripheral inputs

A

what are the 5 emetic control centers?

31
Q

tron

A

what is the ending of the anti-serotonin 5HT drugs?

32
Q

corticosteroids, cannabinoid, benzodiazepines

A

other drugs useful for nausea

33
Q

cholinergic agents, dopamine receptor antagonists, serotonin receptor modulation, motilin-like agents

A

GI motility agents- prokinetics

34
Q

agonists, and acetycholinesterase inhibitors

A

how do the cholinergic agents work?

35
Q

metoclopramide

A

dopamine receptor antagonist that helps with GI motility and migraines

36
Q

Cisapride, metoclopramide, ondansetron

A

serotonin receptor modulators

37
Q

macrolide abx like: erythromycin, oleandomycin, azithromycin - diabetic gastroparesis, expel bezoars clarithromycin

A

what are the motilin like agents are when are they indicated

38
Q

metformin, GLP-1. sodium-glucose cotransporter 2 inhibitors

A

type 2 diabetic agents that help with modifiying metabolism

39
Q

orlistat

A

lipase inhibitor what work to modify metabolism

40
Q

amphetamine derivatives, serotonin receptor agonists, anti-convulsants

A

anorectic drug classes

41
Q

chronic pain, quit smoking, weight loss

A

atypical anticonvulsant uses

42
Q

morbid obesity, failure of lifestyle modifications

A

when to use anorectic agents

Advanced Pharm (23 decks)

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