anti-inflammatory drug Flashcards
exam 2
Complex of cytologic and chemical reactions in blood vessels in response to aninjury or abnormal stimulation
inflammation
What are the 3 glucocorticoid actions?
glucose production, resistance to stress, hematopoietic anti-inflammatory effects
What are 4 more glucocorticoid effects?
gastric (increase acid), calcium mobilization from bone, mental status, anti-emetic effects
What are the adverse effects of glucocorticoids?
hyperglycemia, impaired healing, bone loss, adrenal suppression
Adrenal suppression has a reduced tolerance of these 3 things
trauma, sepsis, anesthesia
What are common preps of glucocorticoids?
methylprednisone (IM), dexamethasone (IV/IM), prednisone (oral), triamcinolone (topical), flunisolide & fluticasone (aerosol)
What 2 glucocorticoids for joint injections?
methylprednisone (IM), triamcinolone (topical),
Indications for glucocorticoids?
reduce inflammation, suppress immune system,major surgical procedures, cancer chemo
What are the glucocorticoids associated with accelerating fetal lung maturation
betamethasone, beclamethasone, dexamethasone
This is an autacoids that include prostaglandins and leukotrienses
eicosanoids
Arachidonic acid +cyclooxygenase
prostaglandis, thromboxans
arachidonic acid + lipoxygenase
leukotrienes
This cyclooxygensase isoform is ubiquitous, physiologics
Cox-1
This cyclooxygensase isoform is induced by inflammation
Cox-2
What are two drugs of the salicylate family?
ASAl diflunsal
What are 3 main salicylate toxicities?
GI irritation, renal, anticoagulation effects
This is a fatty liver disease and encephalopathy. greatest risk is when infectious fever develops
reye’s syndrome
What are the 2 well known propionic acid derivatives?
ibuprofen, naproxen
This indolacetic acid has a very strong anti-inflammatory action but great velocity
indomthacin
This NSAID is an “other” and is very useful in acute pain given IM or IV
Ketrolac (Toradol)
Cox-2 inhibitor for arthritis and have GI disorders
Celecoxib
T/F: All NSAIDs probably increase CV disease risk to at least some degree
True
NSAID that is Dr. Dodge’s favorite bc it has a low CV risk
Naproxen
T/F, acetaminophen affects platelets.
False
Why do we have to watch the dose with acetaminophen?
hepatic toxicity (dose dependent or idiosyncratic)
What is the recommended max daily dose of acetaminophen?
4 g, 12 tablets/day
Name alert of acetaminophen outside of the US?
paracetamol
