anti-inflammatory drug

Question 1

Complex of cytologic and chemical reactions in blood vessels in response to aninjury or abnormal stimulation

Answer 1

inflammation

Question 2

What are the 3 glucocorticoid actions?

Answer 2

glucose production, resistance to stress, hematopoietic anti-inflammatory effects

Question 3

What are 4 more glucocorticoid effects?

Answer 3

gastric (increase acid), calcium mobilization from bone, mental status, anti-emetic effects

Question 4

What are the adverse effects of glucocorticoids?

Answer 4

hyperglycemia, impaired healing, bone loss, adrenal suppression

Question 5

Adrenal suppression has a reduced tolerance of these 3 things

Answer 5

trauma, sepsis, anesthesia

Question 6

What are common preps of glucocorticoids?

Answer 6

methylprednisone (IM), dexamethasone (IV/IM), prednisone (oral), triamcinolone (topical), flunisolide & fluticasone (aerosol)

Question 7

What 2 glucocorticoids for joint injections?

Answer 7

methylprednisone (IM), triamcinolone (topical),

Question 8

Indications for glucocorticoids?

Answer 8

reduce inflammation, suppress immune system,major surgical procedures, cancer chemo

Question 9

What are the glucocorticoids associated with accelerating fetal lung maturation

Answer 9

betamethasone, beclamethasone, dexamethasone

Question 10

This is an autacoids that include prostaglandins and leukotrienses

Answer 10

eicosanoids

Question 11

Arachidonic acid +cyclooxygenase

Answer 11

prostaglandis, thromboxans

Question 12

arachidonic acid + lipoxygenase

Answer 12

leukotrienes

Question 13

This cyclooxygensase isoform is ubiquitous, physiologics

Answer 13

Cox-1

Question 14

This cyclooxygensase isoform is induced by inflammation

Answer 14

Cox-2

Question 15

What are two drugs of the salicylate family?

Answer 15

ASAl diflunsal

Question 16

What are 3 main salicylate toxicities?

Answer 16

GI irritation, renal, anticoagulation effects

Question 17

This is a fatty liver disease and encephalopathy. greatest risk is when infectious fever develops

Answer 17

reye’s syndrome

Question 18

What are the 2 well known propionic acid derivatives?

Answer 18

ibuprofen, naproxen

Question 19

This indolacetic acid has a very strong anti-inflammatory action but great velocity

Answer 19

indomthacin

Question 20

This NSAID is an “other” and is very useful in acute pain given IM or IV

Answer 20

Ketrolac (Toradol)

Question 21

Cox-2 inhibitor for arthritis and have GI disorders

Answer 21

Celecoxib

Question 22

T/F: All NSAIDs probably increase CV disease risk to at least some degree

Answer 22

True

Question 23

NSAID that is Dr. Dodge’s favorite bc it has a low CV risk

Answer 23

Naproxen

Question 24

T/F, acetaminophen affects platelets.

Answer 24

False

Question 25

Why do we have to watch the dose with acetaminophen?

Answer 25

hepatic toxicity (dose dependent or idiosyncratic)

Question 26

What is the recommended max daily dose of acetaminophen?

Answer 26

4 g, 12 tablets/day

Question 27

Name alert of acetaminophen outside of the US?

Answer 27

paracetamol