Analgesics Flashcards
Exam 3
With this drug, accidental hepatic necrosis is not rare.
Acetaminophen
Outside of the US, Acetaminophen is known as what?
Paracetamol
Name some antidepressants that have shown some sort of analgesic effect
Duloxetine, desipramime, doxepin, nortriptyline
Name some anticonvulsants showing some superiority to placebo for analgesic effects
topiramate, pregabalin
What are the 3 receptorsubtypes of opioids?
Mu, Delta, Kappa
What are the two indications for opioids?
palliative, non-palliative
What are 3 non-palliative care opioid uses?
surgery, acute injury, chronic pain
T/F Class I DEA drugs are available for RX?
F
What is the gold standard analgesic for severe pain?
morphine sulphate
Describe the fentanyl group
“strong but short acting”
This drug’s antimuscarinic effects help pt not have pinpoint needles
merpidine, Demerol
This drug is a potent opioid agonist that is better for chronic pain and has a slower tolerance and dependence
methadone
This is a partial agonist that has a slow onset but a long half life. Less severe and shorter withdrawal syndrome than methadone.
Buprenorphine
This drug must be converted to morphine by CYP 2D6, 6-10% of population do not have 2D6 activity
Codeine
Acetaminophen + Codeine most common dosage
325 + 30 mg
T/F Partial Opiate Antagonists work well alone
F
T/F opiate dependence is inevitable for all agonists.
T
When does the duration of exposure to an opioid rise for someone at risk for addiction?
7 or more days
7 side effects of opioids.
- sedation and decreased respiration
- increased intracranial pressure
- dysphoria, hallucinations
- n/v
- constipation
- urinary retention
- itching, urticaria
What are the MAO inhibitors of opiates?
hyperpyrexic coma, htn
T/F opioids do not worsen the pain of biliary colic and don’t effect amylase and lipase
F
Can someone with seizures hx take Tramadol?
no
This drug has prompt reversal of opioid overdose but has a short duration of action
naloxone
what is the combo of the short and long acting opioid antagonist?
naltrexone
What numbers are associated with 2016 and 2017 accidental deaths involving opioids?
64k, 47k
most widely abused opioid
extended release oxycodone
What are the social factors that can cause someone to start using?
unhappy circumstances, stresses, limited coping skills… lose of hope
