Analgesics

Question 1

With this drug, accidental hepatic necrosis is not rare.

Answer 1

Acetaminophen

Question 2

Outside of the US, Acetaminophen is known as what?

Answer 2

Paracetamol

Question 3

Name some antidepressants that have shown some sort of analgesic effect

Answer 3

Duloxetine, desipramime, doxepin, nortriptyline

Question 4

Name some anticonvulsants showing some superiority to placebo for analgesic effects

Answer 4

topiramate, pregabalin

Question 5

What are the 3 receptorsubtypes of opioids?

Answer 5

Mu, Delta, Kappa

Question 6

What are the two indications for opioids?

Answer 6

palliative, non-palliative

Question 7

What are 3 non-palliative care opioid uses?

Answer 7

surgery, acute injury, chronic pain

Question 8

T/F Class I DEA drugs are available for RX?

Answer 8

F

Question 9

What is the gold standard analgesic for severe pain?

Answer 9

morphine sulphate

Question 10

Describe the fentanyl group

Answer 10

“strong but short acting”

Question 11

This drug’s antimuscarinic effects help pt not have pinpoint needles

Answer 11

merpidine, Demerol

Question 12

This drug is a potent opioid agonist that is better for chronic pain and has a slower tolerance and dependence

Answer 12

methadone

Question 13

This is a partial agonist that has a slow onset but a long half life. Less severe and shorter withdrawal syndrome than methadone.

Answer 13

Buprenorphine

Question 14

This drug must be converted to morphine by CYP 2D6, 6-10% of population do not have 2D6 activity

Answer 14

Codeine

Question 15

Acetaminophen + Codeine most common dosage

Answer 15

325 + 30 mg

Question 16

T/F Partial Opiate Antagonists work well alone

Answer 16

F

Question 17

T/F opiate dependence is inevitable for all agonists.

Answer 17

T

Question 18

When does the duration of exposure to an opioid rise for someone at risk for addiction?

Answer 18

7 or more days

Question 19

7 side effects of opioids.

Answer 19

1. sedation and decreased respiration
2. increased intracranial pressure
3. dysphoria, hallucinations
4. n/v
5. constipation
6. urinary retention
7. itching, urticaria

Question 20

What are the MAO inhibitors of opiates?

Answer 20

hyperpyrexic coma, htn

Question 21

T/F opioids do not worsen the pain of biliary colic and don’t effect amylase and lipase

Answer 21

F

Question 22

Can someone with seizures hx take Tramadol?

Answer 22

no

Question 23

This drug has prompt reversal of opioid overdose but has a short duration of action

Answer 23

naloxone

Question 24

what is the combo of the short and long acting opioid antagonist?

Answer 24

naltrexone

Question 25

What numbers are associated with 2016 and 2017 accidental deaths involving opioids?

Answer 25

64k, 47k

Question 26

most widely abused opioid

Answer 26

extended release oxycodone

Question 27

What are the social factors that can cause someone to start using?

Answer 27

unhappy circumstances, stresses, limited coping skills… lose of hope