Autonomic I Flashcards
Exam I
involuntary and unconscious
autonomic nervous system is described as ___ and ___
respiration, thermoreg, digestion, reproduction, cardio
systems under autonomic control
Ach, norepi, dopamine, sertonin, histamine, GABA
important neurotransmitter
agonist
effect is similar
antagonist
effect is opposite
cholingeric
effect is pertaining to acetylcholine
muscarinic
acetylcholine receptor subtype that produces parasympathetic responses
nicotinic
acetylcholine receptor subtype that produces sympathetic response like tachy
acetylcholinesterase (AChE)
enzyme that degrades acetylcholine
catecholamine and adrenergic
epinephrine and norepi are these terms
eccrine
these sweat glands have both autonomic division interventions
apocrine
only have adrenergic receptors (axilla and genitals)
sympathetic
uterus relaxation
parasympathetic
bladder detrusor contraction
parasympathetic
sexual arousal
brief
how long is the duration of action of Ach?
modified Ach
What is the reasoning behind giving a modified Ach?
ocular, GI, and bladder, MS, Dementia
What are some indications for Cholinenergic drugs?
M1
Muscarinic Receptor Subtype: ANS nerves
M2
Muscarinic Receptor Subtype: heart, ANS nerves, smooth muscle
M3
Muscarinic Receptor Subtype: glands, smooth muscles, endothelium
Pralidoxime
Drug that reverse AChE action
edrophonium
What drugs causes a pt to feel stronger when they are getting tested for MG?
miosis
Cholingenergic Adverse Effects- occular
Atropine, Scopolamine, Ipratropium & tiotropium
Cholingenergic Antagonist “Antimuscarinic Agent”
sweating (eccrine)
Cholingenergic Adverse Effects- sweat glands
diarrhea, nausea, abdo cramps
Cholingenergic Adverse Effects- GI
bronchospasm
Cholingenergic Adverse Effects-pulmonary
urinary urgency
Cholingenergic Adverse Effects-urinary
bradycardia/syncope
Cholingenergic Adverse Effects- cardiac
mydriasis (pupil dilation)
anticholinergic adverse effects-eyes
tachy
anticholinergic adverse effects- cardio
constipation
anticholinergic adverse effects- GI
pee retention
anticholinergic adverse effects-urinary
block secretion
anticholinergic adverse effects- eccrine sweat glands
confusion/delerium
anticholinergic adverse effects-sensorium
some bronchodilation
anticholinergic adverse effects-pulmonary
10mg= hallucinations, 0.5 slight affects
Atropine dosing 0.5-10mg
scopolamine
motion sickness tx, can cause hallucination and short term memory loss (antimuscarinic drug)
ipratropium & tiotropium
These anticholingeric drugs are for asthma and COPD, but not both
not for chronic use, but used in electrotherapy and controlled hypotenstion
Ganglion Blocking Drugs (Hexamethonium, mecamylamine, Trimethaphan)
tubocurarine
Neuromuscular blockade drug- nondepolarizing agent used in surgery for intubation
Depolarizing Agent, succinylcholine
Neuromuscular blockade drug- fast acting with short duration
surgery, ICU, Psych
Indications for neuromuscular blockage drugs