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Advanced Pharm > Behavioral Med II > Flashcards

Behavioral Med II Flashcards

1
Q

This is the mos common type of psychoses

A

idiopathic

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2
Q

This type of psychoses includes some endrocrine and neurodegenerative disorders

A

psychoses d/t medical conditions

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3
Q

This type of psychoses is from meds, drugs, and toxins

A

toxic psychoses

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4
Q

What are the two types of psychosis symptoms

A

positive and negative

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5
Q

What do almost all antipsychotic drugs have as their MOA?

A

dopamine receptor D2 blocking effect

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6
Q

What do dopamine agonsists aggravate?

A

schizophrenia

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7
Q

This drug is approved for Parkinson’s disease psychosis and has no D2 blocking effect

A

Pimavanserin

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8
Q

This antipsychotic drugs block D2 receptors and reduce dopamine in the forebrain

A

first generation antipsychotic drugs

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9
Q

What are the high potency effects of first generation antipsychotic drugs

A

extrapyramidal tract- parkinson like

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10
Q

What are the low potency effects of first generation antipsychotic drugs

A

sedation, hypotension, autonomic side effects

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11
Q

What are the atypical agents for antipsychotic drugs called atypical?

A

less extrapyramidal effects

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12
Q

What are the major problems with the atypical antipsychotics?

A

weight gain, DM, hypercholesterolemia

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13
Q

1st generation antipsychotics butyronphenones

A

haloperidol

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14
Q

1st generation antipsychotics thioxanthenes

A

thiothixene

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15
Q

Name 3 atypical antipsychotics

A

olanzapine, risperidone, clozapine

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16
Q

Antipsychotic drug side effects

A

extrapyramidal, antimuscarininc, alpha adrenenergic, dopamine inhibition

17
Q

The are antimuscarinic side effects of antipsychotic drugs

A

dry mouth, blurred vision, constipation, urinary retention

18
Q

The alpha adrenergic side effects of antipsychotic drugs

A

orthostatic Hypotension, ejaculatory dysfunction

19
Q

The dopamine inhibitory side effects of antipsychotic drugs

A

hyperprolactinemia, galactorrhea, gynecomastia

20
Q

T/F Tardive dyskinesisa may resolve after discontinuation of neuroleptic drugs lke Haldol

A

F

21
Q

What is the main cardiac effect of antipsychotics?

A

prolonged QT intervals

22
Q

What generation of antipsychotic drugs safe for pregnancy?

A

1st generation

23
Q

From the CATIE study, what drug had the lowest discontiuation rate?

A

Olanzapine

24
Q

What are the greatest risks of Olanzapine?

A

wt gain, diabetes, hyperlipidemia

25
Q

T/F, early treatment with antipsychotic drugs produces better results

A

T

26
Q

What drugs are including in the methylxanthines

A

caffeine, theophylline, theobromine

27
Q

T/F nicotine is more addictive than heroin

A

T

28
Q

What is the main benefit from the use of nicotine?

A

relief of withdrawal symptoms

29
Q

What are the side effects of Varenicline (Chantix)?

A

nausea, increased suicide ideation (?)

30
Q

What are the key chemical effects of cocaine?

A

accentuates norepinephrine, depletes dopamine

31
Q

What are the indications of amphetamines?

A

ADHD, nacrolepsy, obesity

32
Q

What is included in the withdrawal syndrome of amphetamines?

A

paranoid psychosis, resembles schizophrenia

33
Q

What drugs are associated with cognitive enhancement?

A

amphetamines, methyphenidate, modafinil

34
Q

What are the indications of the non-amphetamine drug, Modafinil?

A

narcolepsy, somnolence d/t sleep apnea, work shift related somnolence

35
Q

What are the 3 stimulant commonalities?

A

addiction, withdrawal, used/abused

Advanced Pharm (23 decks)

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