Behavioral Med II Flashcards
This is the mos common type of psychoses
idiopathic
This type of psychoses includes some endrocrine and neurodegenerative disorders
psychoses d/t medical conditions
This type of psychoses is from meds, drugs, and toxins
toxic psychoses
What are the two types of psychosis symptoms
positive and negative
What do almost all antipsychotic drugs have as their MOA?
dopamine receptor D2 blocking effect
What do dopamine agonsists aggravate?
schizophrenia
This drug is approved for Parkinson’s disease psychosis and has no D2 blocking effect
Pimavanserin
This antipsychotic drugs block D2 receptors and reduce dopamine in the forebrain
first generation antipsychotic drugs
What are the high potency effects of first generation antipsychotic drugs
extrapyramidal tract- parkinson like
What are the low potency effects of first generation antipsychotic drugs
sedation, hypotension, autonomic side effects
What are the atypical agents for antipsychotic drugs called atypical?
less extrapyramidal effects
What are the major problems with the atypical antipsychotics?
weight gain, DM, hypercholesterolemia
1st generation antipsychotics butyronphenones
haloperidol
1st generation antipsychotics thioxanthenes
thiothixene
Name 3 atypical antipsychotics
olanzapine, risperidone, clozapine
Antipsychotic drug side effects
extrapyramidal, antimuscarininc, alpha adrenenergic, dopamine inhibition
The are antimuscarinic side effects of antipsychotic drugs
dry mouth, blurred vision, constipation, urinary retention
The alpha adrenergic side effects of antipsychotic drugs
orthostatic Hypotension, ejaculatory dysfunction
The dopamine inhibitory side effects of antipsychotic drugs
hyperprolactinemia, galactorrhea, gynecomastia
T/F Tardive dyskinesisa may resolve after discontinuation of neuroleptic drugs lke Haldol
F
What is the main cardiac effect of antipsychotics?
prolonged QT intervals
What generation of antipsychotic drugs safe for pregnancy?
1st generation
From the CATIE study, what drug had the lowest discontiuation rate?
Olanzapine
What are the greatest risks of Olanzapine?
wt gain, diabetes, hyperlipidemia
T/F, early treatment with antipsychotic drugs produces better results
T
What drugs are including in the methylxanthines
caffeine, theophylline, theobromine
T/F nicotine is more addictive than heroin
T
What is the main benefit from the use of nicotine?
relief of withdrawal symptoms
What are the side effects of Varenicline (Chantix)?
nausea, increased suicide ideation (?)
What are the key chemical effects of cocaine?
accentuates norepinephrine, depletes dopamine
What are the indications of amphetamines?
ADHD, nacrolepsy, obesity
What is included in the withdrawal syndrome of amphetamines?
paranoid psychosis, resembles schizophrenia
What drugs are associated with cognitive enhancement?
amphetamines, methyphenidate, modafinil
What are the indications of the non-amphetamine drug, Modafinil?
narcolepsy, somnolence d/t sleep apnea, work shift related somnolence
What are the 3 stimulant commonalities?
addiction, withdrawal, used/abused
