Hypothalamus Flashcards
What 3 functions does the hypothalamus regulate in concern to homestasis?
- Autonomic
- Endocrine
- Behavior
From what parts of the body does the hypothalamus receive sensory signals?
- All parts (vision, olifactory, somatosensory, etc….)
How does the hypothalamus use the sensory signals it receives to assess homeostasis?
Compares levels with set biological check points
How many hormones does the hypothalamus release?
8
How can the hypothalamus control blood pressure and electrolyte balance with behavior?
- Drinking water
- Intake of salt
How can the hypothalamus regulate body temperature through the ANS?
Shivering
How can the hypothalamus control energy metabolism?
- Feeding
- Digestion
- Metabolic rate
How can the hypothalamus control reproduction?
Behavior: Sexual drive
Hormones: Pregnanct, lactation, etc
If the hypothalamus receives information from the periphery about an imbalance that can be solved hormonally, how does it get that message to peripheral glands?
- Hypothalamus produce releasing or inhibiting factors
- These factors are secreted into a portal system into the pituitary gland
- Adenohypophysis produces and stores secondary releasing factors
- Secondary releasing factors reach the peripheral glands which promote their own hormones for systemic circulation
What are the only 2 hormones not produced via the adenohypophyseal system?
- Oxytocin
- Antidiruetic hormone
By what type of system are oxytocin and ADH released to systemic circulation?
Neurohypophyseal system
Describe the release of oxytocin and ADH by neurohypophyseal systems?
- Hypothalamus produces the hormones
- Hormones travel by axoplasmic flow via the hypohypophseal tract to the neurophypophysis in the posterior pituitary gland
- When needed, action potentials cause the release of the hormone into systemic circulation
Which portion of the ANS do posterior aspects of the hypothalamus correspond to?
Sympathetic nervous system
Which portion of the ANS do anterior aspects of the hypothalamus correspond to?
Parasympathetic nervous system
Which portion of the hypothalamus inhibits the other portion of the hypothalamus?
Anterior inhibits posterior
By what tract does the hypothalamus reach the frontal lobe and limbic system, affecting behavior?
Mammilothalamic tract
What structure separates the medial and lateral groups of the hypothalamus?
The columns of the fornix
How do the medial and lateral nuclei of the hypothalamus correspond to one another?
They serve the opposite functions.
For example)
Arousal vs Sleep
Rage vs Docility
etc..
What are the 3 portions of the medial nuclear group?
Anterior
Middle
Posterior
What is an important nucleus in the anterior medial group related to biological rhythms?
- Suprachiasmatic nucleus (drives circadian rhythms)
What is the hypothesis for hypothalamic regulation of body fat and food consumption called?
Lipostatic hypothesis
Describe the lipstatic hypothesis.
- Body weight has a stable baseline (if animal is starved, it gains back weight after it is fed, and vice versa)
- Leptin regulates body mass, decreases appetite, and increases energy expenditure
- When leptin is depleted, the adaptive responses to fight starvation are activated
Is the lateral hypothalamus or the ventromedial hypothalamus responsible for feeding drive? Which is responsible for inhibition?
Drive: Lateral hypothalamus
Inhibition: Ventromedial hypothalamus
What are 2 ways to stimulate eating?
- Excite feeding center
- Damage/ disinhibit inhibitory center
How does the arcuate nucleus respond to elevated leptin levels?
- Release alpha-MSH and CART peptides, which diminish appetite
Where is the arcuate nucleus located?
On the base of the 3rd ventricle
What 3 areas does the arcuate nucleus project to to inhibit appetite?
- Paraventricular nucleus
- Intermediolateral gray matter of spinal cord
- Lateral hypothalamus
What effect do decreased leptin levels have on the arcuate neurons?
Release NPY and AgRP, which increase appetite through the 3 methods
Which ANS is stimulated when leptin is low?
Parasympathetic to stimulate feeding
How do the orexigenic (feeding peptides) increase appetite?
Inhibit secretion of TSH and ACTH
How long do hormonal processes of the hypothalamus take to have effect?
Days/ weeks
What peptide neurotransmitter informs the cortex about leptin levels?
MCH
What behavior affects the motivation to eat?
- When you ate your last meal
- How big it was
Describe the interplay between the desire for food (orexigenic signals), food consumption, and hormonal/ chemical satiety signals.
- Food consumption begins when orexigenic signals are greatest,
- Food consumption continues slightly after satiety signals have begun to climb, and they climb even higher after food consumption has commenced
- Satiety signals then drop as orexigenic signals begin to climb again
(Dr. A says eat, and then WAIT before seconds to allow you satiety signals to catch up)
What are the 3 phases of appetite, eating, disgestion, and satiety?
- Cepahlic
- Gastric
- Substrate
What are 3 signals of satiety?
- Gastric distension
- Cholecystokinin
- Insulin
What is the “liking” conception of why we eat?
Hedonic
What is the “wanting” conception of why we eat?
Drive reduction