Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

MD3001 > Hypersensitivity > Flashcards

Hypersensitivity Flashcards

1
Q

what type is this?
IgE
soluble antigen
mast cell activation

A

type 1- allergy and asthma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

what type is this?
IgG
cell surface receptor or matrix
activates complement

A

type 2 drugs and chronic urticaria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

what type is this?
IgG
soluble antigen
activates complement

A

type 3 - arthus reaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q 
Th1 and 2 cells or cytotoxic t cell
soluble antigens or cell antigens
macrophage and eosinophil activation
cytotoxicity
dermatitis, chronic asthma, allergic rhinitis
A

Type 4

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

what does IgE trigger

A

mast cell degranulation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

what is IgE produced by

A

plasma B cells in lymph nodes or locally

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

what does a CD4 t helper 1 cell cause

A

macrophage activation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

what does CD4 TH2 cause

A

B cell acitvation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

what does a CD8 cytotoxic t cell cause

A

cell lysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

name some allergens

A 
pollen 
animals 
mold spores
dust mite faeces
insect venom 
vaccines
drugs
medicine
food
plants
synthetic chemicals 
metals
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

what is degranulation

A

is a cellular process that releases antimicrobial cytotoxic molecules from secretory vesicles called granules found inside some cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

what can result from an allergen entering the blood stream

A

hives (urticaria)

anaphylaxis and cv collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

name some inflammatory mediators

A

lipids
toxic mediators
cytokines
enzymes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

what cell favours IgE response

A

Th2 T cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

what cell is stimulated in allergy and asthma

A

mast cell usually found at mucosal surfaces

soluble antigen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

what type would you find non soluble antigens

A

type 2

cytoxic

17
Q

what cells are stimulated in type 3

A

phagocytes

immune complex disease

18
Q

what cells are stimulated in type 4

A

macrophages and eosinophils

delayed type hypersensitivity

19
Q

what do prostaglandins do

A

increase vascular permeability
increase platelet aggregation
activates neutrophils

20
Q

what do chemokines do

A

attract macrophages and neutrophils

21
Q

what other cells are also involved In allergy

A

basophils and eosinophils

can cause tissue damage

22
Q

what type involves IgG

A

2 and 3

23
Q

what antibodies are involved in type 3 (immune complex)

A

IgG and IgM

24
Q

where might immune complexes be deposited in type

A 
kidneys
blood vessels
synovial membranes
skin
 systemic
25
Q

what are the features of type 4

A 
complement is not involved 
entirely cell mediated 
delayed hypersensitivity (DTH)
involves macrophages
granulomas eg tubercles seen in tuberculosis

MD3001 (33 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions