fungal infections and treatment Flashcards
what does Cryptococcus neoformans cause
meningitis, pneumonia, fungaemia
a type of yeast
what does pityriasis versicolor causes
chronic skin infections
a type of yeast
what does histoplasma capsulatum cause
pulmonary or disseminated infections
a type of yeast
what does aspergillus cause
pulmonary, ocular infections, bronchopulmonary aspergillosis, fungaemia
a type of filamentous fungi
what do dematophytes cause
skin, nail infections
a type of filamentous fungi
what are the main types of antifungal drugs
triazoles, imidiazole, thiazole flucytosine polyenes terbinafine griseofulvin echinocandins allyamines
what does triazole do
blocks p450 and sterol 14 alpha demethylase in the cell wall
what does flucytosine do
inhibits protein synthesis
what do polyenes do
pore formation in fungal membranes
what does terbinafine do
inhibits squalene epoxidase that accumulates toxic sterols in the cell wall
what does griseofulvin do
inhibits fungal mitosis
what do echinocandins do
inhibit 1,3 beta glucan in the cell wall
what are some examples of triazole drugs
fluconazole
itraconazole
posaconazole
voriconazole
what are some examples of polyenes
amphotericin and nystatin
what are the 4 types of triazoles
fluconazole
itraconazole
posaconazole
voriconazole
