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MD3001 > Cancer chemotherapy > Flashcards

Cancer chemotherapy Flashcards

1
Q

form covalent bonds with nucleophilic substances

A

Alkylating agents

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2
Q

nitrogen mustard

A

alkylating agent

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3
Q

nitrosourea

A

alkylating agent

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4
Q

platinum compounds

A

alkylating agent

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5
Q

cisplatin

A

platinum based alkylating agent

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6
Q

cyclophosphamide

A

nitrogen mustard alkylating agent

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7
Q

lomustine, carmustine

A

nitrosoureas

effective against brain tumours due to ability to cross BBB

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8
Q

Busulphan

A

chronic granulocytic leukaemia aka chronic myeloid leukaemia

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9
Q

methotrexate

A

antifolate (antimetabolite)

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10
Q

gemcitabine

A

antipyramidine (antimetabolite)

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11
Q

antipurine

A

mecaptopurine, thioguanine

antimetabolite

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12
Q

fludarabine

A

antipurine

inhibits DNA polymerase

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13
Q

doxorubicin

A

anticancer anthracycline antibiotic

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14
Q

daunorubicin, idarubicin, epirubicin, aclarubicin, and mitoxantrone (mitozantrone

A

anthracycline

affects topoisomerase 2

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15
Q

Dactinomycin

A

Cytotoxic antibiotic

interferes with RNA polymerase

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16
Q

Bleomycin

A

Cytotoxic antibiotic

metal-chelating glycopeptide antibiotic

17
Q

Mitomycin

A

Cytotoxic antibiotic

bifunctional alkylating agent

18
Q

Vincristine, vinblastine

A

Vinca alkaloids (plant derivatives)

19
Q

Paclitaxcel (taxol), docetaxel

A

Taxanes

plant derivatives

20
Q

irinotecan

A

Camptothecins

plant derivatives

21
Q

Etoposide

A

plant derivative

inhibits mitochondria, nucleoside transport and topoisomerase 2

22
Q

tamoxifen

A

Hormone antagonist used in breast cancer

23
Q

Procarbazine

A

inhibits DNA and RNA synthesis and interferes with mitosis

24
Q

Hydroxycarbamide

A

inhibits ribonucleotide reductase

25
Q

Crisantaspase

A

active against acute lymphoblastic leukaemia cells

26
Q

Amsacrine

A

topoisomerase II

27
Q

Mitotane

A

stops synthesis of adrenocortical steroids

28
Q

what are the 4 classes of plant derivatives

A

vinca alkaloids
taxanes
camptothecins
etoposide

29
Q

vinca alkaloids

A

bind tubulin

30
Q

taxans

A

stabilises microtubules

31
Q

camptothecins

A

bind to and inhibit topoisomerase 1

32
Q

etoposide

A

inhibits mitochondrial function and topoisomerase 2

MD3001 (33 decks)

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