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PA30245 Infection and Immunity > Hepatitis C > Flashcards

Hepatitis C Flashcards

1
Q

What viral family does Hep C belong to?

A

Flaviviridae

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2
Q

What is the most common source of Hep C infection in the UK

A

IV drug users

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3
Q

What percentage of people are asymptomatic in the acute phase of hepatitis infection?

A

50-90%

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4
Q

What is normal ALT level?

A

5-35IU/l

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5
Q

Which genotype is most common in the west?

A

Genotype 1

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6
Q

What can be used to diagnose Hep C?

A 
HCV viral load measure
LFTs
Fibroscan
Rarely liver biopsy
Imaging
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7
Q

What does fibroscan do?

A

Measures liver elastography

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8
Q

Where does Hep C replicate?

A

Cytoplasm

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9
Q

What is ribavirin?

A

Nucleoside guanosine analogue

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10
Q

How does ribavirin work?

A

Interferes with viral replication.

Nucleoside inhibitor

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11
Q

What are the problems with interferon?

A 
Systemic flu-like symptoms.
Fatigue.
Depression.
Cytopenia
Rashes
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12
Q

Name 5 NS3/4 Protease inhibitors

A 
Telaprevir
Boceprevir
Simeprevir
Paraprevir
Grazoprevir
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13
Q

Name 2 polymerase inhibitors

A

Sofosbuvir

Dasabuvir

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14
Q

Name 5 NS5A inhibitors

A 
Ledipasvir
Daclatasvir
Ombitasvir
Velpatasvir
Elbasvir
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15
Q

How does telaprevir work?

A

Protease inhibitor targeting the HCV NS3/4A protease enzyme in combination with PEG/RBV

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16
Q

How does bocepravir work?

A

Linear peptidomimetic ketoamide serine NS3 protease inhibitor

17
Q

Name some HCV treatment combinations

A

Ombitasvir/paritaprevir/ritonavir+/- dasabuvir

Elbasvir and grazoprevir

Velpatsavir and Sofosbuvir

18
Q

What is sofosbuvir?

A

HCV NS5B RNA polymerase inhibitor

19
Q

How does ombitasvir work?

A

Inhibits NS5A

20
Q

How does paritaprevir work?

A

Inhibits NS3-4A serine protease

21
Q

How does zepetavir work?

A

NS5A inhibitor

22
Q

How does grazoprevir work?

A

NS3/4A inhibitor

23
Q

How does velpatasvir work?

A

NS5A inhibitor

PA30245 Infection and Immunity (30 decks)

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