Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

PA30245 Infection and Immunity > Asthma inflammation and allergy > Flashcards

Asthma inflammation and allergy Flashcards

1
Q

What are allergens?

A

Antigens that elicit an allergic response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What is anaphylaxis?

A

Acute severe allergic reaction resulting in respiratory collapse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the inflammatory extrinsic features of allergy and asthma?

A

Atopic
Young onset
Hyperresponsive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What are the inflammatory intrinsic features of allergy and asthma?

A

Non-atopic
Middle aged +
Hyperresponsive
More severe airflow limitation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the development of allergy driven by?

A

T helper lymphocyte subset (Th2 cells) and their products (Th2 cytokines)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What cytokines do Th1 produce?

A

Interferon-y

IL-12

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What cytokines do Th2 produce?

A

IL-4 and IL-13
IL-5
IL-9

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What factors favour the Th1 phenotype?

A

Presence of older siblings
Early exposure to day care
TB, measles or hep A infection
Rural environment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What factors favour Th2 phenotype?

A 
Widespread use of antibiotics
Western lifestyle
Urban environment
Diet
Sensitisation to house dust mites and cockroaches
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Th1 cytokines stimulate or express Th2 production?

A

suppress

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which cytokines switch B lymphocytes to make IgE antibody?

A

IL-4 and IL-13

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

IgE fixes onto what on the surface of tissue mast cells?

A

FceR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Which immunoglobulin is relatively rare in plasma?

A

IgE

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What does E stand for in IgE?

A

Erythematous

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What causes degranulation of mast cells?

A

Cross linking of FceR1-bound IgE on the mast cell surface

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the mast cell products?

A

Histamine
TNF & other cytokines
Proteases
Heparins

17
Q

Which mast cells have low histamine?

A

Lung

18
Q

Which mast cells have high histamine?

A

Skin

19
Q

Name 3 membrane derived lipid mediators of inflammation

A

Leukotrienes
Prostanoids
PAF

20
Q

What role do LTC4 and LTD4 have in asthma?

A

Potent constriction of airway smooth muscle

Increase vascular permeability

21
Q

What role do LTB4 have in asthma?

A

No direct bronchoconstriction

Chemotactic for leukocytes

22
Q

What role does PGE2 have in asthma?

A

Relaxes airway smooth muscle
May decrease leukocyte activation
Sensitises irritant receptors

23
Q

What role does PGD2 have in asthma?

A

Chemotactic

Bronchoconstrictor

24
Q

What are the actions of IL-13 (and IL-4)?

A

Increase eosinophil adhesion and migration.
Increase mucus secretion.
Tissue remodelling.
Increase airway smooth muscle cotractility

PA30245 Infection and Immunity (30 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions