Chronic inflammation Flashcards
What is the main purpose of chronic infection?
To bring cells from the blood to the site of infection
What is chronic inflammation?
Abnormal response to prolonged stimulation leading to further tissue damage and scarring
Is RA more prevalent in men or women?
Women
Why aren’t NSAIDs ideal to treat this inflammatory response?
They inhibit COX enzymes which make prostaglandins. PGs are not the main drivers of this inflammatory response.
RA affects what % of UK adult population?
0.8%
When do RA patients usually have remission?
During pregnancy
What is chronic inflammation largely mediated by?
Cytokines
What increase leukocyte adhesion to the endothelium?
TNF
IL-1
What happens to stimulate macrophages and cyto T cells to cause tissue damage?
Th1 cells secrete IFNy
Presentation and response to ag is dependent upon what?
MHC alleles
What do Th2 release?
Anti inflammatory cytokines IL-4
What cytokines are prototype inflammatory?
TNF
IL-1
What cytokines are prototype antiinflammatory?
IL-4
IL-10
