Hematopoiesis

Question 1

Formed Elements in Blood

Answer 1

PIC

Question 2

Hematopoiesis in Fetus

Answer 2

Ontogeny follows phylogeny

Question 3

Phylogeny of Lymphoid Tissues in Vertebrates

Answer 3

PIC

Question 4

Bone Marrow can be taken from bones to be tested for cancer– taken from where?

Answer 4

In Babies:
Shaft of Tibia

Adults:
Sternum, Vertebrae, Iliac Spine (Anterior/Superior)

Question 5

Hematopoiesis

Answer 5

Process of blood cell production

Question 6

Hematopoiesis: Hemocytoblast

Answer 6

Pluripotential stem cell-common precursor to all blood cell types

Question 7

Hematopoiesis: Myeloid Stem Cell

Answer 7

Multipotential lineages-capable of self renewal

Question 8

Hematopoiesis: megakaryocyte

Answer 8

form platelets/thrombocytes fragments of megakaryocytes

Question 9

Hematopoiesis: monocytes

Answer 9

monocytes that leave blood become macrophages

Question 10

Hematopoiesis: Lymphoid Stem Cells

Answer 10

multipotential lineages capable of self renewal

-Lymphocytes
T Lymphocytes: Cellular immunity
B Lymphocytes: Humoral Immunity

Question 11

Red Bone Marrow

Answer 11

is active. Hematogenous (young)

Question 12

Yellow Blood Marrow

Answer 12

Adipose cells (older)
Has been replaced with fat cells

Question 13

Vascularity of Bone Marrow

Answer 13

PIC

Question 14

Hematopoietic Compartment:

Answer 14

• Stromal Cell (hematopoietic inductive microenvironment)
• Venous Sinusoids

(pic)

Question 15

Structure of Bone Marrow: Endothelial Cell

Answer 15

Form a continour layer of interconnected cells lining the blood vessels. A basal lamina seperates endothelial cells from the branching stromal cell (PIC)

Question 16

Structure of Bone Marrow: Granulocyte Progeny

Answer 16

Developing granulocytes are found adjacent to venous sinusoids. Mature grandulocytes leave the bone marrow by diapedesis

Question 17

Structure of Bone Marrow: Stromal/Reticular Cell

Answer 17

Branching stromal cells form a ceullular network under endothelial lining. Stromal cells produce hematopoletic short-range regulatory meolecules induced by colony stimulating factors

Question 18

Structure of Bone Marrow: Macrophage

Answer 18

Engulf nuclei ectruded from orthochromatic erythroblasts before their conversion to reticulocytes

Question 19

Structure of Bone Marrow: Megakaryocyte

Answer 19

Discharges proplateles into the lumen thouhg an epithelial cell gap

Question 20

Structure of Bone Marrow: Nutreint Arteriole

Answer 20

A branch of the nutrient artery is surrounded by hematopoietic cells

Question 21

Bone Marrow is a reservoir of preserved DNA

Answer 21

Saber toothed tiger related to Clouded leopard (found by long lasting marrow over HUNDREDS of years)

Question 22

What does erthropoietin stimulate?

Answer 22

Red blood cell mitosis

Question 23

Stages of Erthropoiesis

Answer 23

PIC (4)

Question 24

Normoblast characteristic

Answer 24

Nucleus pushed to the side

Question 25

Reticulocyte

Answer 25

Nucleus is removed

Question 26

____% of the RBC in blood are reticulocytes

Answer 26

1%

Question 27

Granulopoiesis: Promomyelocyte

Answer 27

nonspecific granules- first azurophillic granules being secreted in golgi zone, developed golgi complex

Question 28

Granulopoiesis: Myelocyte

Answer 28

Specific Granule: Moderate number of azurophilic granules and initial secretion of specific granules in golgi zone developed golgi complex

Question 29

Granulopoiesis: Metamyelocyte

Answer 29

Lobulation begins | (IDENTIFY): abundant specific granules and few azurophillic granules

Question 30

Granulopoiesis: Myeoblast

Answer 30

No cytoplasmic granules

Question 31

Granulopoiesis: Band Neutrophil accumulation in blood shows....

Answer 31

bacterial infection

Question 32

Thrombopoiesis

Answer 32

PIC

Question 33

Lymphomas

Answer 33

Neoplasm of lymphoid system

Question 34

Lymphomas: Hodgkin's Disease

Answer 34

Characterized by the presence of giant Reed-Sternberd (RS) cells-5 subtypes

Question 35

Lymphomas: Non-Hodgkins Lymphomas

Answer 35

12 B cell types, 12 T cell types

Question 36

Leukemias

Answer 36

Neoplasm of Leukocytes and precursors

Question 37

Leukemias: Acute

Answer 37

immature cells-progress rapidly

Question 38

Leukemias: Chronic

Answer 38

More mature Cells -less aggressive

Question 39

Myelogenous Leukemia

Answer 39

-primarily inolves bone marrow -classified base on type of precursor cell (erythrocyte, granulocytic, monocytic) -Classified into -Acute-Immature cells- rapid progression - Chronic-more mature cells-less aggressive - Tumor cells replace normal hematopoietic tissue