Hematopoiesis Flashcards

1
Q

Formed Elements in Blood

A

PIC

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2
Q

Hematopoiesis in Fetus

A

Ontogeny follows phylogeny

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3
Q

Phylogeny of Lymphoid Tissues in Vertebrates

A

PIC

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4
Q

Bone Marrow can be taken from bones to be tested for cancer– taken from where?

A

In Babies:
Shaft of Tibia

Adults:
Sternum, Vertebrae, Iliac Spine (Anterior/Superior)

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5
Q

Hematopoiesis

A

Process of blood cell production

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6
Q

Hematopoiesis: Hemocytoblast

A

Pluripotential stem cell-common precursor to all blood cell types

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7
Q

Hematopoiesis: Myeloid Stem Cell

A

Multipotential lineages-capable of self renewal

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8
Q

Hematopoiesis: megakaryocyte

A

form platelets/thrombocytes fragments of megakaryocytes

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9
Q

Hematopoiesis: monocytes

A

monocytes that leave blood become macrophages

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10
Q

Hematopoiesis: Lymphoid Stem Cells

A

multipotential lineages capable of self renewal

-Lymphocytes
T Lymphocytes: Cellular immunity
B Lymphocytes: Humoral Immunity

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11
Q

Red Bone Marrow

A

is active. Hematogenous (young)

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12
Q

Yellow Blood Marrow

A
Adipose cells (older)
Has been replaced with fat cells
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13
Q

Vascularity of Bone Marrow

A

PIC

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14
Q

Hematopoietic Compartment:

A
  • Stromal Cell (hematopoietic inductive microenvironment)
  • Venous Sinusoids

(pic)

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15
Q

Structure of Bone Marrow: Endothelial Cell

A

Form a continour layer of interconnected cells lining the blood vessels. A basal lamina seperates endothelial cells from the branching stromal cell (PIC)

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16
Q

Structure of Bone Marrow: Granulocyte Progeny

A

Developing granulocytes are found adjacent to venous sinusoids. Mature grandulocytes leave the bone marrow by diapedesis

17
Q

Structure of Bone Marrow: Stromal/Reticular Cell

A

Branching stromal cells form a ceullular network under endothelial lining. Stromal cells produce hematopoletic short-range regulatory meolecules induced by colony stimulating factors

18
Q

Structure of Bone Marrow: Macrophage

A

Engulf nuclei ectruded from orthochromatic erythroblasts before their conversion to reticulocytes

19
Q

Structure of Bone Marrow: Megakaryocyte

A

Discharges proplateles into the lumen thouhg an epithelial cell gap

20
Q

Structure of Bone Marrow: Nutreint Arteriole

A

A branch of the nutrient artery is surrounded by hematopoietic cells

21
Q

Bone Marrow is a reservoir of preserved DNA

A

Saber toothed tiger related to Clouded leopard (found by long lasting marrow over HUNDREDS of years)

22
Q

What does erthropoietin stimulate?

A

Red blood cell mitosis

23
Q

Stages of Erthropoiesis

A

PIC (4)

24
Q

Normoblast characteristic

A

Nucleus pushed to the side

25
Q

Reticulocyte

A

Nucleus is removed

26
Q

____% of the RBC in blood are reticulocytes

A

1%

27
Q

Granulopoiesis: Promomyelocyte

A

nonspecific granules- first azurophillic granules being secreted in golgi zone, developed golgi complex

28
Q

Granulopoiesis: Myelocyte

A

Specific Granule: Moderate number of azurophilic granules and initial secretion of specific granules in golgi zone developed golgi complex

29
Q

Granulopoiesis: Metamyelocyte

A

Lobulation begins

(IDENTIFY): abundant specific granules and few azurophillic granules

30
Q

Granulopoiesis: Myeoblast

A

No cytoplasmic granules

31
Q

Granulopoiesis: Band Neutrophil accumulation in blood shows….

A

bacterial infection

32
Q

Thrombopoiesis

A

PIC

33
Q

Lymphomas

A

Neoplasm of lymphoid system

34
Q

Lymphomas: Hodgkin’s Disease

A

Characterized by the presence of giant Reed-Sternberd (RS) cells-5 subtypes

35
Q

Lymphomas: Non-Hodgkins Lymphomas

A

12 B cell types, 12 T cell types

36
Q

Leukemias

A

Neoplasm of Leukocytes and precursors

37
Q

Leukemias: Acute

A

immature cells-progress rapidly

38
Q

Leukemias: Chronic

A

More mature Cells -less aggressive

39
Q

Myelogenous Leukemia

A

-primarily inolves bone marrow
-classified base on type of precursor cell
(erythrocyte, granulocytic, monocytic)
-Classified into
-Acute-Immature cells- rapid progression

  • Chronic-more mature cells-less aggressive
  • Tumor cells replace normal hematopoietic tissue