HEMATOPOEISIS Flashcards
Blood is 45% cells, also know as pecent packed cell volume
____________ indicator of anemia, polycythemia and other conditions
hematocrit
60%
transports lipids, steroid hormones
albumin
transport ions, many different proteins with a variety of functions
has a globulin classes alpha, beta and gamma
35%
globulins
granular leukocytes (granulocytes)
neutrophils eosinophils basophils
agranular leukocytes (agrunolocytes)
lymphocytes monocytes
in early week of embryo period ____ is the site of hemopoiesis
yolk sac
location of blood cell formation is the second trimester of pregnancy
liver spleen lymph node
3rd trimester location of blood cell formation
bone marrow
develops into RBS
proerythroblasts
develop into basophils, neutrophils, and eosinophils
myeloblasts
develop into lymphocytes
lymphoblasts
develop into monocytes
monoblasts
develop into platelets
megakaryoblasts
all blood cells are formed from _______ to committed cells
pluripotential hematopoietic stem cells
promotes the growth and reproduction of all the different types of stem cells whereas others induce growth of a specific type of committed stem cells
interleukin 3
committed stem cells lose their capacity for self-renewal, they become irreversibly committed
progenitor cells
plasma membrane contain _____ an elastic spectrin an elastic protein give erythrocytes their flexibility or bag-like
spectrin
indication of mean corpuscular hemoglobin (MCH)
ex. hyper/hypochromic, normochromic
chromasia
cells of abnormal size; indication of mean corpuscle volume (MCV)
example is micro/macrocytic, normocytic
anisocytosis
cells of abnormal shape in red blood cells
sickle cell, spherocytosis
poikilocytosis
_____________ causes RBC to cluster and increases their effective density
fibrinogen
made up of two alpha and two beta chains a protein
globin
iron containing pigemnt part which binds with oxygen
heme group
most common in an adult human hemoglobin which is the combination of 2 alpha and 2 beta chains
hemoglobin A
hemoglobin bound to oxygen, oxygen loading takes place in the lungs
oxyhemoglobin
hemoglobin after oxygen diffuses into tissues (reduced Hb)
deoxyhemoglobIn
hemoglobin bound to carbon dioxide, carbon dioxide loading takes place in tissues
carbaminohemoglobin
valine is substituted for glutamic acid when exposed to low oxygen tension
sickle cell anemia
due to congenital absence of dihydronicotinamide adenine dinulceotide (NADH) methemoglobin reductase system that converts methemoglobin back to hemoglobin
hereditary methemoglobinemia
formed if blood is exposed to certain drug or oxidizing agent which converts ferrous to ferric ion
methemoglobin
iron that binds to protein
apotransferrin
iron travels in circulation
transferrin
extremely insoluble; toxic to cells; iron overload
hemosiderin
final stage before mature RBC, released into blood where final maturation occurs
reticulocyte
stimulates RBC production
formed in response to hypoxia
erythropoietin
in people living in high altitude where atmospheric oxygen is low
polycythemia
due to genetic abberation in the hemotocytoblastic cells that produce blood cells
increase in total blood volume
increase viscosity of blood
polycythemia vera
