GI Pharm Overview

Question 1

sympathetic nervous system has what effect on the GI smooth muscles

Answer 1

Relaxes muscle, contracts sphincters, inhibits secretion….overall it just slows it down

Question 2

Parasympathetic nervous system has what effect>?

Answer 2

opposite of sympathetic

Question 3

Anti-cholinergics do what

Answer 3

Basically mimic the SNS. Remember that Ach is the primary neurotransmitter in all autonomic ganglia and also serves as the transmitter between parasympathetic ganglia and their effector cells.

Question 4

SLUDGEBBB

Answer 4

Cholinergic excess. Salivation, Lacrimation, Urination, Defecation, GI upset, Emesis

Question 5

Cholinergic insufficiency leads to

Answer 5

The opposite oo SLUDGE BBB plus CNS effects

Question 6

Major Neurotransmitters of the ENS

Answer 6

• Ach: The primary NT and major ganglionic transmitter. (Ach is excitatory for smooth muscle and and glands)
• Dopamine: a modulatory NT in the ENS
• Enkephaline
• Serotonin

Question 7

Vomitting is controlled by what

Answer 7

Dopamine and Serotonin signal to the vomitting center in the brain with signals vagal efferents to the GI to relax smooth muscle and cause somatic (voluntary) wretching.

Question 8

Vomitting center in the brain located where?

Answer 8

Area postrema