Chronic Liver Injury

Question 1

Chronic Liver Injury is associated with what

Answer 1

Chronic Inflammation and chronic ongoing repair and scarring

Question 2

The liver has a unique way of scarring which we call

Answer 2

Cirrhosis

Question 3

The Inflammation associated with chronic viral hepatitis usually involves what area of the liver

Answer 3

Portal triads

Inflammation tends to be focal

Question 4

When, during chronic hepatitis, the inflammation extends out from the portal triads obscuring the hepatocyts that form the limiting plate (The layer of hepatocytes right next to the portal triad…this is called:

Answer 4

Interface hepatitis

Question 5

Chronic active hepatitis characterized by?

Answer 5

This limiting plate invasion (Interface hepatitis)

Question 6

Interface hepatitis has no predictive value regarding the evolution of the disease

Answer 6

ok

Question 7

In acute liver injury, the liver can re-generate up to 75% of the liver. However, the problem with chronic injury is that the repair response gets in the way of regeneration and you get scarring (Cirrhosis)

Answer 7

ok

Question 8

Hepatic repair response is led by which cells

Answer 8

Stellate Cells

Question 9

What the hell do Stellat cells do?

Answer 9

They differentiate into myofibroblasts and secrete collagen and other ECM substances into the space of Disse

Question 10

I nchronic hepatits, where does the deposition of fibrous repair material take place

Answer 10

Periportal region…..this process is termed FIBROUS PORTAL EXPANSION

Question 11

In alcoholic liver disease, the injury is generally where

Answer 11

Centrolobular………..This means fibrosis develops along the central veins and you get what is referred to as central sclerosis

Question 12

What type of collagen is present in the space of DIsse in a normal liver?

Answer 12

Type IV collagen

Question 13

What type of collagen is present in the space of Disse in liver with chronic injury undergoing ongoing repair

Answer 13

Type I and III