Enteric Viruses

Question 1

What is the structure of the Rotavirus?

Answer 1

Segmented, double stranded RNA, non-enveloped with 2-3 icosahedral capsids

Question 2

What is the single most important cause of severe diarrheal illness of infants and young children world wide

Answer 2

Rotavirus

Question 3

What is significant about the fact that Rotavirus’ genome is segmented?

Answer 3

It can undergo antigenic shift and antigenic drift which gives it high antigenic diversity.

Question 4

What is the unique seasonal appearance of Rotavirus in teh US

Answer 4

Winter and Spring

Question 5

WHat serotype causes the majority of disease in humans?

Answer 5

4 G-P….THIS IS THE BASIS FOR ITS VACCINE DEVELOPMENT

Question 6

What generates the infectious viral particle in rotavirus infection

Answer 6

The proteolytic processing viral capsid particles either outside of enterocytes or intra-enterocyte–> infectious viral particle

Question 7

mRNA transcription of Rotavirus genome is

Answer 7

Asymmetrical…Only + strand RNAs are made

Question 8

KNOW that during Rotavirus replication, capped +RNA strands serve as a template for -RNA strands.

Answer 8

ok

Question 9

Virus assembly of rotavirus occurs where

Answer 9

cytoplasm

Question 10

RotaTeq

Answer 10

Live attenuated pentavalent bovine-human reassortment virus containing G1-G4 and P8

Question 11

Rotarix

Answer 11

live attenuated divalent human virus containing Gi, P8

Question 12

Norovirus structure

Answer 12

Non-segmented, +RNA, Non-enveloped

Question 13

What is the most important cause of foodborne epidemic and acute gastroenteritis in in older children and adults?

Answer 13

Norovirus

Question 14

Winter vomitting disease?

Answer 14

Noravirus

Question 15

Both Noravirus and Rotavirus are extremely stable in the environment. why?

Answer 15

Both are non-enveloped

Question 16

Both Rota and Noro initially infect the villus epithelium of the small intestine. This causes the loss of the cells which line these.

Answer 16

Glucose coupled sodium transport is impaired, but adenylate cyclase and cAMP are not stimulated.

Question 17

Enterovirus, coxsackie virus, and Echovirus are all members of what viral subfamily

Answer 17

Picornaviridae

Question 18

poliovirus causes

Answer 18

flacid paralysis

Question 19

coxsackie virus causes

Answer 19

meningoencephalitis, diarrhea, muscle pain, myocardial infarction

Question 20

Echovirus causes mild gastritis

Answer 20

ok

Question 21

Where do enteroviruses originally replicate?

Answer 21

Lymphoid tissue of the upper respiratory tract and gut

Question 22

Meningitis is caused by which of the enteroviruses?

Answer 22

Poliovirus, Coxsackie, Echovirus (PCM)

Pts almost always fully recover from this

Question 23

Pleurodynia is what

Answer 23

Epidemic myalgia…characterized by the abrupt onset of fever, chest, and abdominal pain. Pain is spasmodic and usually resolves in 2 weeks

Question 24

Pleurodynia caused by what?

Answer 24

Group B coxsackie virus

Question 25

Hand foot and mouth disease associated with what virus?

Answer 25

Coxsackie A16

Question 26

Hand, foot, and mouth characterized by what?

Answer 26

Ulcerative lesions on mucosa and mouth.

Question 27

Myocarditis cause

Answer 27

Group B coxsackie