Enteric Viruses Flashcards
What is the structure of the Rotavirus?
Segmented, double stranded RNA, non-enveloped with 2-3 icosahedral capsids
What is the single most important cause of severe diarrheal illness of infants and young children world wide
Rotavirus
What is significant about the fact that Rotavirus’ genome is segmented?
It can undergo antigenic shift and antigenic drift which gives it high antigenic diversity.
What is the unique seasonal appearance of Rotavirus in teh US
Winter and Spring
WHat serotype causes the majority of disease in humans?
4 G-P….THIS IS THE BASIS FOR ITS VACCINE DEVELOPMENT
What generates the infectious viral particle in rotavirus infection
The proteolytic processing viral capsid particles either outside of enterocytes or intra-enterocyte–> infectious viral particle
mRNA transcription of Rotavirus genome is
Asymmetrical…Only + strand RNAs are made
KNOW that during Rotavirus replication, capped +RNA strands serve as a template for -RNA strands.
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Virus assembly of rotavirus occurs where
cytoplasm
RotaTeq
Live attenuated pentavalent bovine-human reassortment virus containing G1-G4 and P8
Rotarix
live attenuated divalent human virus containing Gi, P8
Norovirus structure
Non-segmented, +RNA, Non-enveloped
What is the most important cause of foodborne epidemic and acute gastroenteritis in in older children and adults?
Norovirus
Winter vomitting disease?
Noravirus
Both Noravirus and Rotavirus are extremely stable in the environment. why?
Both are non-enveloped
Both Rota and Noro initially infect the villus epithelium of the small intestine. This causes the loss of the cells which line these.
Glucose coupled sodium transport is impaired, but adenylate cyclase and cAMP are not stimulated.
Enterovirus, coxsackie virus, and Echovirus are all members of what viral subfamily
Picornaviridae
poliovirus causes
flacid paralysis
coxsackie virus causes
meningoencephalitis, diarrhea, muscle pain, myocardial infarction
Echovirus causes mild gastritis
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Where do enteroviruses originally replicate?
Lymphoid tissue of the upper respiratory tract and gut
Meningitis is caused by which of the enteroviruses?
Poliovirus, Coxsackie, Echovirus (PCM)
Pts almost always fully recover from this
Pleurodynia is what
Epidemic myalgia…characterized by the abrupt onset of fever, chest, and abdominal pain. Pain is spasmodic and usually resolves in 2 weeks
Pleurodynia caused by what?
Group B coxsackie virus
Hand foot and mouth disease associated with what virus?
Coxsackie A16
Hand, foot, and mouth characterized by what?
Ulcerative lesions on mucosa and mouth.
Myocarditis cause
Group B coxsackie
