GI Disease in Pigs Flashcards
Discuss GI disease in Pigs?
- GI dz very common
- Major economic loss to industry
- Direct –death, treatment
- Indirect –slow-growth, poor performance
- May be infectious or non-infectious
- Viruses, bacteria & protozoa common causes
- Rapid and accurate diagnosis vital
- Diarrhoea is primary clinical sign
- Also: sudden death, vomiting, perineal staining
What can be seen here?

Staining on pigs legs and peri- anal staining clues to GI disease
Describe pre-weaning infections (0-4 weeks old)?
Pre-weaning (0-4wks old)
1. Rotavirus
2. Colibacillosis
3. Coccidiosis –Isosporasuis
4. Clostridialenteritis
5. Corona viruses -TGE- PED -HEV
Describe post-weaning infections (>4 weeks old)?
Post-weaning (> 4ks old)
1. Post-weaning colibacillosis
2. Proliferative Enteropathy –ileitis
3. Spirochaetaldiarrhoea (Colitis)
4. Salmonellosis
5. Brachyspira–swine dysentery
6. Yersiniosis
7. GI torsions
8. Gastric ulcers
9. Parasites –Trichuris, Ascaris, Eimeria(rare)
Discuss Post-weaning colibacillosis
- Common worldwide
- Usually occurs within 10 days after weaning
- E. coli with specific attachment factors and verotoxins– do not cause physical damage
- Watery yellow diarrhoea stimulated by verotoxins
- Pig usually alert and eating
- Often recover OK if treated
What can be seen here?

E. coli disease –watery yellow diarrhoea 7 to 10 days after weaning

Post weaning collibacillosis management/treatment?
- Watery yellow diarrhoea
- Most commonly vaccines given to sows to pass on immunity
- Sow vaccines (gletvax6) –protect piglets
- Piglet vaccines (oral/live –not popular)
- Control with zinc oxide (in-feed, soon to be banned as spreads into watercourse)
- Apramycin, paramomycin, florfenicol (antibiotics not to be used preventably only when disease present)
- Acidification of water
- Diets with lower CP (crude protein) will help – Downside is pigs don’t grow.
- Highly digestible diet, source of lactose, gradual feed change, increased hygiene
- Get lab diagnosis and c+s and toxins
- If shigatoxins present –will be oedema disease not diarrhoea – sudden death
Name all the different manifestations of Porcine Proliferative Enteropathy Complex -Ileitis?
1.Porcine Intestinal Adenopathy (PIA) chronic disease in growers
2. Necrotic Enteritis (NE) young growing pigs
3. Regional Ileitis (RI) chronic watery diarrhoea
4. Proliferative haemaorrhagic enteropathy (PHE) -Acute haemorrhagic disease in finishers and breeders

What is this?

Lawsonia intracellularis
Surveys show very common globally
What are the facts of Ileitis?
Ileitis Facts
- Duration of diarrhoea -3 days to 3 months
- Shedding of Lawsonia
- –90% -only 3 weeks
- –10% -3 to 12 weeks
- Persistent shedders
- Lawsonia viable in faeces for 2 weeks
- Low infectious dose
- Each faecal output can contain 100’s of infective doses –faeco-oral transmission
- Lawsonia easily spreads around a farm (sows/older growers)
- Endemic disease –triggered by diet change/environment; severity dependent on dose
Discuss PIA: PIA -porcine intestinal adenomatosis -chronic and subclinical ileitis?
- Endemic on many farms
- Lesions vary from mild to severe in many herds and situations
- Causes variation in pigs, subclinical and clinical cases

How is PIA diagnosed?
Faeces: PCR (unvalidated)
Post Mortem: ‘Hosepipe’ ileum
Histopathology: pathognomonic – gut degradation can impact diagnosis

What kind of Ileitis is this?

Diarrhoea due to Chronic Ileitis
- 6 to 20 week-old pigs
- Mild to severe
- Brown-grey-green diarrhoea
- Not mucoid
- Non-haemorrhagic in the chronic and sub- clinical forms
- Pigs with weight loss
- Variable growth rates6 to 20 week-old pigs
- Mild to severe
- Brown-grey-green diarrhoea
- Not mucoid
- Non-haemorrhagic in the chronic and sub- clinical forms
- Pigs with weight loss
- Variable growth rates
What has happened here?

PHE - Proliferative haemaorrhagic enteropathy
- Usually young adults –4-12 months
- Sudden deaths
- Blood in faeces
- Anaemic
- Rare
- Twisted gut?
- Tylosin
- Sporadic in nature, rare
What is this?

Ileitis vaccine
- effective but challenging to use (expensive)
- Oral and live –can’t be used alongside AB’s
What effective antibiotics are there for ileitis?
Effective antibiotics include
- Tiamulin, Tylosin, Lincomycin: -may have superior intracellular effect
- no evidence of resistance
Pig challenge and field studies completed –In-feed (chronic) and soluble antibiotics (acute outbreak) have similar efficacy –Good products for treatment of ileitis problems
Introduce swine dystentry?
- Swine dysentery charter (optional)–AHDB (must be reported)
- Caused by the microaerophilic spirochaete Brachyspira hyodysenteriae.
- Causes often severe muco-haemorrhagic colitis usually in growing pigs (6-14 weeks), but can also see disease in sows.

What is this and what does it cause?

Brachyspira hyodysenteriae
Causes swine dysentry
Discuss swine dysentery further?
- An expensive disease with a profound impact on production
- Conservative estimates of 25g/day lost live weight gain and 0.2 FCR (Feed Conversion Rate).
- Mortality can be significant, especially in older pigs
- Medication costs £4-5 per pig
- Total costs £6-10 per pig, equating to £50,000 annually for a 500 sow Farrow to Finish farm.
- Difficult to live with
How is swine dysentery diagnosed?
- Clinical signs and gross post mortem findings +/- histopathology
- Faecal sample
- PCR (16s RNA)
- Culture
- NO USEFUL SEROLOGICAL TEST
Discuss epidemiological problems faced when trying to control swine dysentery?
- Faeco-oral infection but incubation period may be 7-60 days.
- Carriers may remain subclinically infected for up to 90 days.
- Organism can survive in moist faeces for 40 days at 50C and 60 days if diluted in tap water.
- Dry warm conditions kill it more quickly.
- Rapidly killed by disinfectants if used appropriately.
- Mice, rats, dogs, flies and cockroaches have been shown to be able to transmit the organism.
What can be seen here?

Mucoid bloody faeces typical of Brachyspira sp. problems
What can be seen here?

Major effect of Swine Dysentery on breeding pigs
What can be seen here?

Haemorrhages and excess mucus in colon, 18 week old (SD)












