GI - ANDERSON Flashcards

1
Q

What cells secrete Histamine in the ST?

what triggers this?

A

Gastrin from G cells trigger ECL-cells to release Histamine which stimulates the Proton Pump and release of Gastric H+

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2
Q

What are the cells of the Duodenum and Jejunum that secrete and aid in digestion?

A

K –> GIP -> stimulate beta cells to release insulin
I -> CCK -> release of bile
S -> secretin -> stim. pancrease and GB to release BICARB

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3
Q

K cells of the SI release?

A

GIP

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4
Q

I cells of the SI release?

A

CCK

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5
Q

What is absorbed in the terminal ileum?

What about Iron?

A

bile salts and B12

- iron is absorbed in the duodenum

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6
Q

Primary Bile Acids

A

Cholic Acid

Chenodeoxycholic

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7
Q

Secondary Bile Acids are converted from primary via what?

A

bacteria in the SI

  • Deoxycholic
  • Lithocholic
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8
Q

Conjugation of bile acids makes BILE SALTS which is done by the _____ with AA’s _____ and ______.

A

LR

- GLYCINE, TAURINE

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9
Q

RLE enzyme of bile acid synthesis?

A

7-alpha hydroxylase

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10
Q

B3, NAC, is used in what kinds of rxns?

Xu is called?

A

DEHYDROGENASE RXNS

Xu –> Pellagra

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11
Q

Remember, B5 is …

A

CoA

- pantothenic acid

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12
Q

Active form of B6 is…

A

pyridoxal 5-phosphate

  • AA metabolism
  • needs Mg as cofactor
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13
Q

Homocysteine -> Methionine

vitamin needed?

A

B12 - COBALAMIN

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14
Q

B12 also frees _____ to make THF.

A

FOLATE

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15
Q

Vit C used in what type of RXNs?

A

HYDROXYLATION

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16
Q

Biotin used in what type of RXNs?

A

CARBOXYLASE

- if you eat too much raw egg, you will not absorb biotin

17
Q

A stored mainly in LR as?

A

Retinyl Palmitate

18
Q

E stored mainly in ?

A

FAT

19
Q

Various forms of Vit D:
SKIN:
LR:
KD:

A

SKIN - D3 or Cholecalciferol
LR - 25 hydro D3
KD - 1-25-dihydro D3

20
Q

D3 is made from what with the help of UV light?

A

7-hydroxycholesterol

21
Q

25 hydro D3 can make two forms of D in the KD depending on Ca levels and PTH.
+PTH —>
-PTH —>

A

+PTH —> 1-25 dihydro D3 (increase serum Ca)

-PTH —> 24-25 dihydro D3 (decreases serum Ca)

22
Q

Selenium is part of?

protects against?

A

Glutathione peroxidase

- mercury poisoning - heavy metals

23
Q

Cobalt is part of vitamin?

A

B12 hence COBAlamin

24
Q

CoQ10 is located where?

- made w cholesterol

A

ETC

  • also an antioxidant
  • made in the cholesterol pathway
25
Q

Glutathione is a tripeptide made of?

A

Step 1: Glutamate + Cysteine
…. Cysteine is rate limiting component
…. w enzyme GGCS
Step2: Glycine added w GSH enz (glutathione synthetase)

26
Q

Glutathione is preserved by?

A

Vit C