FOM 6.2.3 Flashcards
What are each of these on the histological slide?
Epidermis
Dermis
Hypodermis
What are the cell types in the epidermis?
Keratinocytes - epidermal skin cells
Merkel cells - tactile receptors
Langerhans cells - macrophages
Melanocytes - derived from neural crest cells
What are each of these cell layers?
Top to bottom
Stratum corneum, lucidium, granulosum, spinosum, and basale
What is the underlying etiology of psoriasis?
Infiltrating immune cells synthesize and release cytokines that signa; proliferation and thus lead to a reduced length of cell cycle. Turnover is reduced to three to four days.
Answer the following
D - Cytokines from infiltrating lymphocytes
What is filaggrin?
It induces the aggregation of keratins
What is are lamellar bodies?
The place where lipids form
The formation of the water barrier is cause by what?
What is lamellar ichthyosis caused by?
A mutation in the TGM 1 gene which leads to a defective transglutaminase protein.
What would you find in dermatitis herpetiformis?
Autoantibodies to transglutaminase, a gluten intolerance and IgA deposits
What is a melanocyte?
It originates from the neural crest and it creates melanosome that travel to the nearby keratinocyte.
What is a langerhans cell?
It is a peripheral dendritic cell that presents antigens to the immune complex.
What is a merkel cell?
These are tactile mechanoreceptors that associate with the basal lamina. It has a short axon
What is the target antigen of pemphigus vulgaris?
The target antigen for pemphigus vulgaris is desmoglein (DSG) 3
Pemphigus foliacues has autoantibodies to what?
DSG1