FOM 5.1.3 Flashcards
What are each of these?
What are the major characteristics of this cell?
- granules contain major basic protein and other proteins that kill parasites
- contain histaminase that limits the inflammatory process
- can phagocytose antigen-antibody complexes
What are the characteristics of this cell?
- band neutrophil
- immature neutrophil
- aka stab cell
What are the characteristics of these?
- Maintain hemostasis
- Serotonin
- ADP
- Thromboxane A2
- Adhere to endothelium promote vessel repair, blood clotting and vasoconstriction
What is this cell and what are the identifying characteristics?
Basophil - large dense granules
What are each of these cells?
Top left- neutrophil
Top right - monocyte
Bottom left - monocyte
Bottom right - basophil and platelets
What are the characteristics of this cell?
Neutrophil
Migrate to sites of infection and phagocytose bacteria
What are the characteristics of this cell?
Monocyte - will become tissue macrophage
What is the role of a basophil?
Plays a role in hypersensitivity reaction
Secretes histamine
What is this cell and what are the defining characteristics?
Neutrophil - multilobed nucleus and relatively small abundant granules
What are each of these cell types?
Top Left picture - left lymphocyte ; right monocyte
Top right - Monocytes
Bottom left - eosinophil
What will lymphocytes further differentiate into?
T-cells and B-cells
What are each of these cells?
Top left - basophil
Top right - eosinophil
Bottom right - neutrophil
What are each of the cells in this image?
Top left picture - left neutrophil, middle monocyte, right basophil
Right - neutrophil
Bottom left - monocyte
What are each of these?
Top left - basophil
Top right - band cell and mature segmented neutrophils
Bottom left- eosinophil
Bottom right - erythrocyte
What is this and what are the defining characteristics?
Eosinophil - electron dense and electron lucent regions within the same granule
What are each of these cells?
Top left - lymphocyte
Right - basophil
Bottom left - left - lymphocyte right - eosinophil
What are each of these?
Left - basophil
Right - lymphocyte
What are each of these?
What are each of these?
Top neutrophil
Bottom - monocyte
What is this?
Sickle cell anemia
What is this?
Microcytic anemia - note small erythrocytes
What is this?
Macrocytic anemia - note the very large erythrocytes
What is this large cell taken from the bone marrow and what does it produce?
Megakaryocyte - produces platelets it will remain in the bone marrow compartment and shed platelets into the vascular space
These are?
Plasma cells
What is the composition of whole blood?
55% plasma and 45% erthrocytes and the buffy coat with platelets and leukocytes
What is the difference between serum and plasma?
Serum contains an anticoagulant so there is no fibrinogen
What are the two types of bone marrow and what are their differences?
Yellow - not producing blood cells
Red - actively producing blood cells
What is the controlling mechanism of erythropoiesis?
Oxygen tension is sensed in the kidney. Release of EPO which leads to increased proliferation, decreased apoptosis, increased hemoglobin production, increased reticulocyte release
What is mean corpuscular volume?
Size of the RBC
What is MCHC?
Mean corpuscular hemoglobin concentration - Hb concentration per cell
What is MCH?
Mean corpuscular hemoglobin - weight of Hb per cells
What is RDW?
Red cell distribution width - variation in size
What are some of the effects of abnormally high glycation on erythrocyte function?
Increased adhesion to endothelium
Decreased membrane fluidity
Decreased BPG activity
