FOM 2.3.1

Question 1

What are labeled as 1, 2 and 3 and what types of proteins do these use?

Answer 1

1. Tight Junctions (Claudins)
2. Adherens Junction (Cadherins)
3. Desmosomal Junction (Cadheins)

Question 2

What does each of the number designate?

Answer 2

1. JAM
2. Occludin
3. Claudin
4. ZO-1
5. ZO-2
6. ZO-3
7. actin

Question 3

What does each of the numbers designate?

Answer 3

1. Plasma Membrane
2. Catenin
3. Vinculins
4. alpha-actinin
5. Actin filaments

Question 4

What does each of the numbers designate?

Answer 4

1. Attachment plaque (desmoplakin and plakoglobins)
2. Plasma membrane
3. Keratin (intermediate filaments)
4. Cadherins

Question 5

What does each of the numbers designate?

Answer 5

1. BP230
2. BP180
3. Plectin

Question 6

What does each of the numbers designate?

Answer 6

1. Talin
2. Vinculin
3. alpha-actinin
4. FAK (Focal Adhesion Kinase)
5. Src Kinase
6. RAS
7. RAF
8. Grb2
9. SoS

Question 7

What is the importance of occludens in the gut?

Answer 7

The zonulla occludens functions to seal the lumen of the gut from the rest of the body. This is obviously important since the lumen of the gut is technically the outside of the body. The occludens junction is of great importance in water balance and the transport of molecules from the lumen of the gut to the basal fluid.

Question 8

What are the proteins that make up a gap junction?

Answer 8

A gap junction consists of a six protein hemipore of connexion that will line up and dock with another six protein hemipore.

Question 9

How does mechanical stress interact with focal adhesions?

Answer 9

Mechanical stress will result in the activation of kinases associated with the focal adhesion. That will then go to the nucleus and affect transcription.