FOM 3.1.1

Question 1

What is the complication that Xiaobin Lu is facing?

Answer 1

His two medicines are interacting w/ eachother (buspirone & erythromycin)

Question 2

Why are busprione & erythromycin interacting w/ eachother?

Answer 2

Both utilize the CYP3A4 pathway (member of Cyt P450 family of enzymes)

Question 3

How does erythromycin affect the digestion & absorption of buspirone?

Answer 3

Erythromycin inhibits buspirone digestion, which increases it’s serum levels.

Question 4

What is the recommended course of action?

Answer 4

Bactrim, it uses an alternate digestive pathway.

Question 5

Why can’t a patient take aspirin & ibuprofen?

Answer 5

ibuprofen is a competitive inhibitor of COX1 that outcompetes ASA.

Question 6

What is the recommendation if a patient is required to take ASA & ibuprofen?

Answer 6

The patient should take the ASA prior to taking the ibuprofen to give it an advantage.

Question 7

Pharmacodynamic interactions

Answer 7

Drugs influence each other’s effects directly

Question 8

Are all drugs acting on the same target additive?

Answer 8

Depends on the biochemical mechanism