Folate Flashcards
is it a trace element, vitamin, or mineral? Folate
B vitamin
what are its three forms? Folate
food, coenzyme, excreted from liver into bile then reabsorbed by intestine
what are the details of its form in food? Folate
not biologically active, bound to glutamates
which form in food is preferred for absorption? Folate
monoglutamate
which is the storage form in food? Folate
polyglutamate
what are the two coenzyme forms? Folate
tetrahydrofolate (THF), dihydrofolate (DHF)
what happens when the intestinal cells are damaged? Folate
it hinders absorption
what are its three functions? Folate
carrier of one carbon compounds, DNA and red blood cell formation
what are the three different carbon compounds it carries? Folate
methanol, formaldehyde, formic acid
what happens with its function in DNA and red blood cell formation? Folate
protein synthesis and cell division
what are the three deficiency symptoms? Folate
macrocytic anemia, smooth tongue, changes in intestinal cells
what is the deficiency symptom macrocytic anemia? Folate
arrested development of rbc: nuclei, large, irregular shape
what happens with the deficiency symptom of changes in intestinal cells? Folate
diarrhea
what are the five predisposing factors of deficiency? Folate
inadequate intake, impaired absorption, enhanced cell multiplication (cancer), drugs, smoking
what are the three things that happens with a deficiency in pregnancy? Folate
neural tube defects in the 1st 3 weeks, spina bifida, anencephaly
