Cobalamin

Question 1

is it a trace element, vitamin, or mineral? Cobalamin

Answer 1

vitamin b12

Question 2

what are its four properties? Cobalamin

Answer 2

high molecular weight, red cyrstalline, in complexes of animal protein, increases proteins biological value

Question 3

whats the result of antibiotics in animals? Cobalamin

Answer 3

increases growth of animal by 15-20% by inhibiting growth of microorganisms that destroy b12

Question 4

what are the first two steps of its unique absorption? Cobalamin

Answer 4

stomach: HCI & intrinsic factor –> binds to haptocorrin (R factor), a salivary glycoprotein

Question 5

what is the third step of its unique absorption? Cobalamin

Answer 5

then split by protease and rebinds to intrinsic factor in duodenum of small intestine and carries to receptors in ileum where absorbed

Question 6

what are the details of the first step of its unique absorption (stomach: HCI and Instrinsic factor)? Cobalamin

Answer 6

HCl acid splits off B12 from protein complexes in food and salivary
protein by denaturing it; proton inhibitor

Question 7

what happens to the elderly in the absorption? Cobalamin

Answer 7

they may produce less acid;

Question 8

what are the details of the second step of its unique absorption (binds to haptocorrin (R factor), a salivary glycoprotein)? Cobalamin

Answer 8

Protects from HCl acid of stomach as it moves through

Question 9

Most deficiencies are due to what? Cobalamin

Answer 9

defects in absorption than diet defects

Question 10

what are its two functions? Cobalamin

Answer 10

Coenzyme involved in transfer of methyl (-CH3) groups; General growth factor and anemia prevention

Question 11

what are the details of its function as: Coenzyme involved in transfer of methyl (-CH3) groups? Cobalamin

Answer 11

Removes a methyl to activate the folate coenzyme (THF); Folate donates methyl to activate Vitamin B12

Question 12

what are the details of its function as: General growth factor and anemia prevention? Cobalamin

Answer 12

Protein and fat metabolism, DNA formation

Question 13

what are the three deficiency symptoms? Cobalamin

Answer 13

Pernicious anemia, Irreversible degeneration of nervous system, Abnormal blood lipids

Question 14

what happens with the deficiency symptom of pernicious anemia? Cobalamin

Answer 14

fatigue

Question 15

what happens with the deficiency symptom of Irreversible degeneration of nervous system? Cobalamin

Answer 15

High dose levels given in brain atrophy

Question 16

what are the four things that can cause inadequate absorption? Cobalamin

Answer 16

Lack of hydrochloric acid or intrinsic factor, Partial or complete removal of stomach, Lack of blood protein that transport, Tapeworm, Elderly

Question 17

what happens with deficiency due to a vegan diet? Cobalamin

Answer 17

May not exhibit anemia due to large intake of folates

Question 18

what are 3 things that cause a deficiency? Cobalamin

Answer 18

Inadequate absorption, Vegan diets, Anemia of folate deficiency

Question 19

how long can deficiency symptom take to appear? Cobalamin

Answer 19

3-6 yrs

Question 20

whats the recommended daily intake? Cobalamin

Answer 20

2.4 micro grams

Question 21

do most diets contain enough? Cobalamin

Answer 21

yes