Final Exam Flashcards
The state of dynamic constancy in the internal environment
Homeostasis
A mechanism that reverses a deviation from the set point (negative = self-corrective)
negative feedback
monitors a physiological value (detect change), which is then reported to the control center
sensors
compares the value to the normal range (set point), if the value deviates too much from the set point, the … activates an effector
control center
causes a change to reverse the situation & return the value to the set point
effector
Stimulus: body temperature exceeds 37 C
Sensor: nerve cells in skin and brain
Control: temperature regulatory center in brain
Effector: sweat glands throughout body
example of negative feedback
regulation of other body systems
- Ex: brain, spinal cord, nerves
nervous system
secretion of regulatory molecules called hormones
- Ex: hormone-secreting glands, such as the pituitary, thyroid, and adrenals
endocrine system
movements of the skeleton
- Ex: Skeletal muscles
muscular system
movement of blood and lymph
- Ex: heart, blood vessels, lymphatic vessels
circulatory system
defense of the body against invading pathogens
- Ex: Bone marrow, lymphoid organs
immune system
gas exchange
- Ex: lungs, airways
respiratory system
regulation of blood volume and composition
- Ex: kidneys, ureters, urethra
urinary system
breakdown of food into molecules that enter the body
- Ex: mouth, stomach, intestine, liver, gallbladder, pancreas
digestive system
continuation of the human species
- Ex: Gonads, external genitalia, associated glands and ducts
reproductive system
protection, thermoregulation
- Ex: skin, hair, nails
integumentary system
movement and support
- Ex: bones, cartilages
skeletal system
1) Increased plasma osmolality stimulates osmoreceptors in the hypothalamus
2) Osmoreceptors in the hypothalamus then stimulate the tract of axons that terminate in the posterior pituitary, causing it to release an antidiuretic hormone into the blood (AKA ADH or vasopressin)
3) ADH acts on the kidneys to promote water retention, so a lower volume of more concentrated urine is secreted
4) The dehydrated person drinks more and urinates less
mechanism of negative feedback
Moves ions across a membrane and creates a difference in charge across that membrane, which is directly dependent on ATP.
primary active transport
Results in the interior being slightly more negative relative to the exterior- electrochemical gradient (which is then used during the second AT)
sodium-potassium pump
It does not directly require ATP: instead, it is the movement of material due to the electrochemical gradient established by primary active transport.
secondary active transport
- ATP is not required, but chemical energy from Na+ moving down its concentration gradient provides energy for glucose to move from high to low concentration
- Requires that proteins have two binding sites (one for each molecule)
- Primary AT will move Na+ back out of the cell, maintaining the gradient
secondary active transport
transported molecules are moved in the same directions
- Ex: Na+ enters the carrier protein (towards ↓ concentration) & glucose enters protein at the same time (towards ↑ concentration)
cotransport (symport)
transported molecules are moved in opposite directions
- Ex: proximal tubules of the kidneys, where sodium ions move from the tubule’s lumen to the tubular cell’s interior, while hydrogen ions are counter-transported into the tubule lumen.
countertransport (antiport)
A naturally occurring phenomenon and does not require the cell to exert any of its energy to accomplish the movement
passive transport
Transport mechanisms that require the cell’s energy, usually in the form of adenosine triphosphate (ATP).
active transport
the diffusion process used for those substances that cannot cross the lipid bilayer due to their size, charge, and/or polarity.
- Ex: Glucose molecules use facilitated diffusion to move down a concentration gradient through the carrier protein channels in the membrane.
facilitated diffusion
- Pump activated by phosphorylation using phosphate from ATP
- Moves 3 Na+ to extracellular fluid & 2 K+ to intracellular (both against concentration gradient)
- Maintains distribution of high intracellular K and low Na
- Transporter high affinity for Na+
- Reduces affinity for Na+ & affinity is now for K+ switching the protein to open back to extracellular side
sodium-potassium pump
random movement of molecules from regions of higher concentration to regions of lower concentrations
diffusion
- concentration gradient
- mass of molecule
- temperature
- solvent density
- solubility
- surface area
- distance traveled
- plasma membrane thickness
factors that affect the rate of diffusion
↑ the difference in concentration, _____ diffusion
↑ (more rapid)
Heavier molecules move _____
more slowly
↑ temp ↑ the energy & molecules movement, _____ diffusion
↑ increase
density of solvent ↑, diffusion rate ____
↓ (decreases)
Nonpolar/lipid-soluble materials pass through plasma membranes more ____ than polar, making them have a _____ diffusion rate
easily; faster
↑ SA, ____diffusion rate, but thicker membranes ____ it
↑ (increases); reduces
↑ distance, ____ diffusion rate
decrease (slower)
graded potential in the postsynaptic membrane that is the result of depolarization and makes an action potential more likely to occur
Excitatory postsynaptic potential (EPSP)
graded potential in the postsynaptic membrane that is the result of hyperpolarization and makes an action potential less likely to occur
Inhibitory postsynaptic potential (IPSP)
- Opening K+ or Cl- channels results in a graded hyperpolarization
- Brings postsynaptic membrane further from threshold(hyperpolarizing)
- Decreasing the likelihood of an action potential
IPSP
- Opening Na+ or Ca 2+ channels results in a graded depolarization
- Brings postsynaptic membrane closer to the threshold (depolarizing)
- Is a graded potential
EPSP
CNS is composed of
brain & spinal cord
- Autonomic nervous center functions: cardio & respiratory
- All ascending & descending tracts between the brain & spinal cord pass through the medulla
- Relay sensory info to the thalamus
functions of the medulla oblongata
neurons that innervate skeletal muscle
- within the CNS
- Voluntary responses; skeletal muscles
- No ganglia
- 1 neuron from CNS to effector
- Type of neuromuscular junction: specialized motor end plate
- Effect of nerve impulse on muscle: excitatory only
somatic nervous system
innervates cardiac muscle, smooth muscle, exocrine/endocrine glands, and adipose tissue/ viscera
- Automatic/ involuntary
- Innervate organs whose functions are not normallyvvoluntarily controlled
- Controls cardiac and smooth muscle, as well as glandular tissue
- Involuntary responses (ex: homeostasis)
- Subdivisions: parasympathetic & sympathetic & enteric (Enteric: nerves innervate the walls of the GI tract)
autonomic nervous system
cell body is in the gray matter of the brain/ spinal cord
- Does not directly innervate organ that will be stimulated
preganglionic
axon extends from autonomic ganglion to effector organ where it synapses in target organ (cardiac & smooth muscles, gland)
postganglionic
one organ receiving sympathetic & parasympathetic input
Dual innervation
- decreases heart rate
- Relaxes bladder sphincter
parasympathetic
- Increases heart rate
- Dilates and constricts veins
- Contracts bladder sphincter
sympathetic
divergence of impulses to ganglia of the sympathetic system and convergence of impulse within ganglia
- Increasing activity in response to fight or flight situations
Mass activation
“Group texts”
- Located in the thoracolumbar (thoracic & lumbar) regions of the spinal cord
- Release of norepinephrine from postganglionic neurons and the secretion of epinephrine from the adrenal medulla
- Heart rate, blood pressure increase
- Blood increases to skeletal muscles, heart and brain: the essentials you need in that moment
sympathetic
- Adrenal medulla is a modified part of the sympathetic nervous system
- Adrenal medulla will secrete norepinephrine and epinephrine
- Epinephrine (adrenaline) from preganglionic sympathetic neurons into the blood
- Norepinephrine from postganglionic sympathetic neurons
Relationship between sympathetic and adrenal medulla
“One-one text”
- Located in the craniosacral (cranial nerves and sacral) portion of the spinal cord
- Releases ACh from postganglionic neurons
- Slows heart rate (decreases the rate of pacemaker cells) and increases digestive activities
- No mass activation (not normally activated as a whole)
parasympathetic
- Sympathetic nervous system
- Release norepinephrine (NE) and epinephrine (epi) from postganglionic neurons only (alpha and beta receptors)
adrenergic
- Parasympathetic nervous system
- Release ACh from preganglionic neurons and from parasympathetic postganglionic neurons
- Different types of receptors:
—–Nicotinic receptors: found on preganglionic cell bodies of ALL autonomic ganglia
—–Muscarinic receptors: found on effector cell membranes
cholinergic
Postsynaptic membrane of:
- All autonomic ganglia
- All neuromuscular junctions
- Some CNS pathways
Depolarization → Excitation
Nicotinic ACh receptors
Produces parasympathetic nerve effects in the heart, smooth muscles, and glands
Depolarization —(k+ channels closed)→ Excitation
- Causes smooth muscles of digestive tract to contract
Muscarinic ACh receptors
G-protein-coupled receptors (receptors influence ion channels by means of G-proteins)
Hyperpolarization —(k+ channels opened)→ Inhibition
- Produces slower heart rate
Muscarinic ACh receptors
- Regulatory hormone controls secretion of anterior pituitary hormone
- Anterior pituitary hormone then controls the secretion of a hormone from another endocrine gland
- The last hormone does the action on its target cell
—Ex: thyroid releases T3 and T4 hormones to do the action intended of this sequence
the sequence of events for hypothalamo-hypophyseal portal hormones
endocrine gland: adrenal medulla
Major hormones: ___
- epinephrine
- norepinephrine
endocrine gland: adrenal cortex
Major hormones: ___
- glucocorticoids (mainly cortisol)
- mineralocorticoids (mainly aldosterone)
endocrine gland: hypothalamus
Major hormones: ___
releasing & inhibiting hormones
endocrine gland: pancreas (islets of langerhans)
Major hormones: ___
- insulin
- glucagon
endocrine gland: pineal gland
Major hormones: ___
melatonin
endocrine gland: pituitary, anterior
Major hormones: ___
trophic hormones
endocrine gland: pituitary, posterior
Major hormones: ___
- antidiuretic hormone
- oxytocin
endocrine gland: thyroid gland
Major hormones: ___
- thyroxine (T4)
- triiodothyronine (T3)
- calcitonin
antidiuretic hormone promotes ___ ___ and vasoconstriction; oxytocin stimulates contraction of ___ and ___ secretory units
water retention; uterus and mammary
posterior pituitary hormones synthesized in hypothalamus
hypothalamo-hypophyseal tract