elm 9.1

Question 1

psychotic episodes are frequently preceded by what is called a ____ phase

Answer 1

prodromal

Question 2

what are negative symptoms in schizophrenia?

Answer 2

person with shiz lack but normal person has it

Question 3

what are positive symptoms in schizophrenia

Answer 3

symptoms that person with schiz has but normal person doesn’t

Question 4

schizoaffective disorder

Answer 4

meets criteria for schizophrenia and also major mood episode

Question 5

dopamine hypothesis for schizophrenia, what is it?

Answer 5

altered dopaminergic activity in certain brain areas play a role in schizophrenia

Question 6

reserpine ____ dopamine and shows ______ in positive symptoms

Answer 6

depletes
improvements

Question 7

amphetamine ____ dopamine and causes ___

Answer 7

releases
psychosis

Question 8

what are the 4 main pathways for dopamine?

Answer 8

mesocortical
nigrostriatal
tubero-infundibular
mesolimbic

Question 9

mesolimbic pathway is important in ____ symptoms

Answer 9

positive

Question 10

mesocortical pathway is important in ____ symptomes

Answer 10

negative

Question 11

HT/pituitary pathway is important in ____

Answer 11

side effects

Question 12

nigrostriatal is important in ___

Answer 12

parkinsons
side effects

Question 13

antipsychotics are nominally dopamine ___ antagonists

Answer 13

D2

Question 14

antipsychotics can also cause _______ dysfunction

Answer 14

pancreatic beta cell

Question 15

what other receptors might be involved in psychosis?

Answer 15

NMDA receptor dynsfunction
serotonin receptors
muscarinic receptors

Question 16

The newest theories about the pathophysiology of schizophrenia hold that the positive symptoms may be due to

a.	 Excess dopamine release in the mesolimbic pathway.

b.	 Excess dopamine release in the associative striatum

c.	 Reduced dopaminergic activity in the mesocortical pathway

d.	 Reduced dopaminergic activity in the mesolimbic pathway

Answer 16

b

Question 17

The newest theories about the pathophysiology of schizophrenia hold that the cognitive symptoms may be due to

a.	 Excess dopamine release in the associative striatum

b.	 Reduced dopaminergic activity in the mesolimbic pathway

c.	 Reduced dopaminergic activity in the mesocortical pathway

d.	 Excess dopamine release in the mesolimbic pathway

Answer 17

c

Question 18

The sedative actions of antipsychotic drugs are primarily due to actions at:

a.	 GABAA receptors

b.	 Histamine H1 receptors

c.	 Muscarinic receptors

d.	 Serotonin receptors

Answer 18

b