ELM 1 Flashcards
Which of the following iGluR subunits binds glycine?
a. GluA1 b. GluK1 c. GluN1 d. GluA2
c
is one of the subunits that comprises the NMDA receptor (clue is in the N) GluN2 and N3 bind glutamate
Which of the following enzymes catalyzes the production of glutamate?
a. Glutamine synthetase b. Glutaminase c. GlnT d. EAAT
b
glutaminase breaks down glutamine to yield glutamate
Which ions are kainate receptors permeable to?
a. calcium b. sodium c. sodium and potassium d. sodium, calcium and potassium
c
There is a large number of potential glutamate receptor subunit combinations. Which of the following types of receptor ONLY forms heterotetrameric complexes?
a. AMPA receptors b. Kainate receptors c. mGluRs d. NMDA receptors
d
NMDA receptors always contain two GluN1 subunits (that bind glycine)
GABA is transported into presynaptic nerve terminals by which transporter?
a. GAT1 b. GAT2 c. GABAT d. EAAT
a
GAT1 = neurons GAT2 = astrocytes
GABAT is GABA transminase and EAAT is excitatory amino acid transporter
How many different glycine receptor α subunits are expressed by humans?
a. 1 b. 2 c. 3 d. 4
c
four genes but one of them (alpha4) is pseudogene and not expressed
A spinal cord, glycinergic, inhibitory interneuron type is the:
a. principal cell b. pyramidal cell c. Renshaw cell d. stellate cell
c
renshaw cells = spinal cord interneurons that regulate motor neurons - stellate cells are interneurons in brain but GABAergic - pyramidal cells = multipolar cells found in the cortex, hippocampus amygdala - principal cells are found in kidney
The GABAA receptor binding site for benzodiazepines is located at the interface of:
a. α and γ2 b. α and β c. γ2 and β d. γ2 and δ
a
BDZ site is at interface of alpha and y2 - delta containing receptors do not bind benzodiazepines
How many subunits do functional GABAB receptors contain?
a. 1 b. 2 c. 3 d. 4
there is one GABAB1 and one GABAB2 subunit
